Detalhe da pesquisa
1.
Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo.
PLoS Pathog
; 20(3): e1012100, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38527094
2.
Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.
PLoS Pathog
; 19(12): e1011872, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096325
3.
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog
; 13(5): e1006372, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28542609
4.
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.
PLoS Pathog
; 12(10): e1005982, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27783669
5.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
J Biol Chem
; 289(50): 34667-82, 2014 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25320088
6.
Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase.
Nat Commun
; 14(1): 1141, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36854765
7.
Profiling DUBs and Ubl-specific proteases with activity-based probes.
Methods Enzymol
; 618: 357-387, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850060
8.
Structure and Function of Viral Deubiquitinating Enzymes.
J Mol Biol
; 429(22): 3441-3470, 2017 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28625850
9.
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Vet Microbiol
; 178(1-2): 132-7, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25975520