Detalhe da pesquisa
1.
Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.
J Am Chem Soc
; 130(38): 12656-62, 2008 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18761444
2.
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
J Med Chem
; 49(15): 4623-37, 2006 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16854068
3.
Structure of an extended-spectrum class A beta-lactamase from Proteus vulgaris K1.
J Mol Biol
; 317(1): 109-17, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11916382
4.
Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme.
J Mol Biol
; 328(1): 289-301, 2003 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12684014
5.
Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J Mol Biol
; 322(1): 111-22, 2002 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12215418
6.
Comparison of beta-lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase.
Protein Sci
; 12(1): 82-91, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12493831
7.
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
J Med Chem
; 47(26): 6556-68, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588091
8.
Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.
Biochemistry
; 43(44): 14111-7, 2004 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15518561
9.
Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes.
J Biol Chem
; 279(10): 9344-52, 2004 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14660590
10.
Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime.
Antimicrob Agents Chemother
; 46(6): 1966-70, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12019116
11.
Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate.
Biochemistry
; 42(45): 13152-9, 2003 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-14609325