Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33766889
3.
siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.
Pharm Res
; 31(12): 3445-60, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980206
4.
Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 24(5): 1417-20, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24485781
5.
Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.
Bioorg Med Chem Lett
; 21(6): 1710-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21324684
6.
Fused heterocyclic M1 positive allosteric modulators.
Bioorg Med Chem Lett
; 21(9): 2769-72, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21055928
7.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
8.
Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 20(8): 2538-41, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20346667
9.
Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 20(8): 2533-7, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303264
10.
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 20(2): 531-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004574
11.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J Med Chem
; 63(22): 13796-13824, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170686
12.
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.
Toxicol Sci
; 172(1): 155-166, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406999
13.
Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography.
Anal Chem
; 80(13): 5168-77, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18481874
14.
Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections.
J Mass Spectrom
; 43(4): 500-8, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18035855
15.
MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate.
ACS Med Chem Lett
; 9(7): 652-656, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034595
16.
Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.
J Med Chem
; 50(16): 3891-6, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17636948
17.
Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
ACS Med Chem Lett
; 5(5): 604-8, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900888
18.
Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.
ACS Med Chem Lett
; 3(12): 1070-4, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900430
19.
Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
J Med Chem
; 54(13): 4773-80, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21682298
20.
Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators.
ACS Med Chem Lett
; 1(6): 263-7, 2010 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900206