Detalhe da pesquisa
1.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Nat Immunol
; 15(3): 231-8, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24464131
2.
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
Nature
; 579(7798): 284-290, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32103175
3.
Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications.
Bioorg Chem
; 143: 106963, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38048700
4.
Tinopanoids K-T, clerodane diterpenoids with anti-inflammatory activity from Tinospora crispa.
Bioorg Chem
; 140: 106812, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37651894
5.
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties.
J Enzyme Inhib Med Chem
; 37(1): 1537-1555, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35670075
6.
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.
Genome Res
; 27(4): 533-544, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28232479
7.
11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells.
Chem Pharm Bull (Tokyo)
; 68(3): 244-250, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32115531
8.
Bone marrow stromal cells transplantation promotes the resolution and recanalization of deep vein thrombosis in rabbits through regulating macrophage infiltration and angiogenesis.
J Cell Biochem
; 120(7): 11680-11689, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30790336
9.
Alleviation of A disintegrin and metalloprotease 10 (ADAM10) on thromboangiitis obliterans involves the HMGB1/RAGE/ NF-κB pathway.
Biochem Biophys Res Commun
; 505(1): 282-289, 2018 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30245136
10.
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors.
Acta Pharmacol Sin
; 39(2): 302-310, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28858300
11.
Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition.
Nucleic Acids Res
; 43(9): 4381-92, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870414
12.
Identification of New Small Molecules as Apoptosis Inhibitors in Vascular Endothelial Cells.
J Cardiovasc Pharmacol
; 67(4): 312-8, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751265
13.
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
J Biol Chem
; 289(30): 20757-72, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24907272
14.
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Proc Natl Acad Sci U S A
; 109(23): 9095-100, 2012 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22586129
15.
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease.
J Biol Chem
; 288(24): 17643-53, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625918
16.
Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants.
Cancer Sci
; 105(1): 117-25, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24205792
17.
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface.
Bioorg Med Chem Lett
; 24(9): 2090-3, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24709560
18.
Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae).
Phytochemistry
; 218: 113932, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38056516
19.
PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma.
Cancer Res
; 84(3): 419-433, 2024 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991725
20.
Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling.
Sci Adv
; 10(13): eadk4423, 2024 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38536911