Detalhe da pesquisa
1.
Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson's Disease Candidate, Using LC-MS/MS and LC-HRMS.
Molecules
; 29(5)2024 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38474516
2.
Synthesis and biological evaluation of quinolone derivatives as transthyretin amyloidogenesis inhibitors and fluorescence sensors.
Bioorg Med Chem
; 53: 116550, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890995
3.
Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies.
Molecules
; 27(6)2022 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35335338
4.
ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype.
Pharmacol Res
; 165: 105423, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434621
5.
Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs.
BMC Vet Res
; 17(1): 295, 2021 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34488750
6.
Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease.
Exp Eye Res
; 180: 8-17, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500363
7.
Enhanced Solubility, In-Vitro Dissolution and Lipase Inhibition of a Self-Nanoemulsifying Drug Delivery System Containing Orlistat.
J Nanosci Nanotechnol
; 19(2): 634-639, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30360134
8.
Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs.
BMC Vet Res
; 14(1): 291, 2018 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249242
9.
Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats.
Xenobiotica
; 48(8): 831-838, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28803538
10.
Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs.
Regul Toxicol Pharmacol
; 81: 387-396, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27664323
11.
Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design.
Bioorg Med Chem Lett
; 25(18): 3947-52, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231159
12.
Hair-growth-promoting effect of conditioned medium of high integrin α6 and low CD 71 (α6bri/CD71dim) positive keratinocyte cells.
Int J Mol Sci
; 16(3): 4379-91, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706512
13.
Simultaneous quantification of methylene blue and its major metabolite, azure B, in plasma by LC-MS/MS and its application for a pharmacokinetic study.
Biomed Chromatogr
; 28(4): 518-24, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24122875
14.
Quantitative determination of enzalutamide, an anti-prostate cancer drug, in rat plasma using liquid chromatography-tandem mass spectrometry, and its application to a pharmacokinetic study.
Biomed Chromatogr
; 28(8): 1112-7, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24424891
15.
Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2.
Chem Biol Interact
; 390: 110886, 2024 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38280639
16.
Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.
Bioorg Med Chem Lett
; 23(13): 3887-90, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23727044
17.
The Development of Super-Saturated Rebamipide Eye Drops for Enhanced Solubility, Stability, Patient Compliance, and Bioavailability.
Pharmaceutics
; 15(3)2023 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986811
18.
Novel Strategy To Inhibit Transthyretin Amyloidosis via the Synergetic Effect of Chemoselective Acylation and Noncovalent Inhibitor Release.
J Med Chem
; 66(4): 2893-2903, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749109
19.
Liquid chromatography-tandem mass spectrometry for quantification of lacosamide, an antiepileptic drug, in rat plasma and its application to pharmacokinetic study.
Biomed Chromatogr
; 26(3): 371-6, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21735462
20.
Clinical Anti-aging Efficacy of Propolis Polymeric Nanoparticles Prepared by a Temperature-induced Phase Transition Method.
J Cosmet Dermatol
; 21(9): 4060-4071, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35001491