Detalhe da pesquisa
1.
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Angew Chem Int Ed Engl
; 63(13): e202316133, 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279624
2.
Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
J Org Chem
; 87(4): 2120-2128, 2022 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582192
3.
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for Highâ pH Dynamic Kinetic Reduction.
Angew Chem Int Ed Engl
; 57(23): 6863-6867, 2018 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29689604
4.
CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development.
J Org Chem
; 77(5): 2299-309, 2012 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22335767
5.
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Bioorg Med Chem Lett
; 21(1): 288-93, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106375
6.
Recent preparative applications of redox enzymes.
Curr Opin Chem Biol
; 49: 105-112, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554005
7.
Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.
Org Lett
; 9(24): 4951-4, 2007 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17973397
8.
Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.
Org Lett
; 18(22): 5888-5891, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27802043
9.
Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.
Org Lett
; 17(6): 1533-6, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754231
10.
Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis.
Org Lett
; 12(17): 3772-5, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20681610
11.
Biocatalytic asymmetric hydrogen transfer.
Angew Chem Int Ed Engl
; 41(6): 1014-7, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12491297
12.
Advances in the enzymatic reduction of ketones.
Acc Chem Res
; 40(12): 1412-9, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18052114
13.
On the organic solvent and thermostability of the biocatalytic redox system of Rhodococcus ruber DSM 44541.
Biotechnol Bioeng
; 81(7): 865-9, 2003 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12557320
14.
Biocatalytic asymmetric hydrogen transfer employing Rhodococcus ruber DSM 44541.
J Org Chem
; 68(2): 402-6, 2003 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12530865
15.
Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions.
Biotechnol Bioeng
; 86(1): 55-62, 2004 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15007841