Detalhe da pesquisa
1.
Pathways to cures for multiple sclerosis: A research roadmap.
Mult Scler
; 28(3): 331-345, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35236198
2.
Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
Bioorg Med Chem Lett
; 31: 127624, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096162
3.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914948
4.
Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.
Bioorg Med Chem Lett
; 23(20): 5684-8, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23993336
5.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem
; 65(5): 4121-4155, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35171586
6.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35261239
7.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35257579
8.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 7): 768-74, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795790
9.
Immunohistochemical visualization of corticotropin-releasing factor type 1 (CRF1) receptors in monkey brain.
J Comp Neurol
; 478(2): 111-25, 2004 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15349973
10.
A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.
J Biomol Screen
; 16(5): 476-85, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21406618
11.
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
J Med Chem
; 54(19): 6548-62, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21882820