Detalhe da pesquisa
1.
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 27(15): 3317-3325, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28610984
2.
Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor.
ACS Med Chem Lett
; 12(6): 1011-1016, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141086
3.
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
ACS Med Chem Lett
; 12(7): 1108-1115, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267880
4.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324999
5.
Controlling cellular distribution of drugs with permeability modifying moieties.
Medchemcomm
; 10(6): 974-984, 2019 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303996
6.
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol Cancer Ther
; 16(7): 1236-1245, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28468779
7.
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J Med Chem
; 58(5): 2180-94, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25679114
8.
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS Med Chem Lett
; 5(10): 1088-93, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313317
9.
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
Nat Med
; 19(2): 202-8, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291630
10.
Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
J Med Chem
; 58(9): 4089, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25933255