Detalhe da pesquisa
1.
Phase 1 drug-drug interaction study to assess the effect of CYP3A4 inhibition and pan-CYP induction on the pharmacokinetics and safety of fosmanogepix in healthy participants.
Antimicrob Agents Chemother
; : e0165023, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38757982
2.
Pharmacokinetics, safety, and tolerability of fosmanogepix IV to oral switch and multiple IV doses in healthy participants.
Antimicrob Agents Chemother
; 68(5): e0145523, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38551346
3.
Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers.
Antimicrob Agents Chemother
; 67(4): e0162322, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36988461
4.
Phase 1b safety and pharmacokinetics of intravenous and oral fosmanogepix in patients with acute myeloid leukaemia and neutropenia.
J Antimicrob Chemother
; 78(11): 2645-2652, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37681450
5.
Absolute Bioavailability of Tasimelteon.
Am J Ther
; 22(5): 355-60, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25658956
6.
Evaluation of intravenous anthrax immune globulin for treatment of inhalation anthrax.
Antimicrob Agents Chemother
; 57(11): 5684-92, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23979731
7.
A pharmacokinetic, pharmacodynamic, and electrocardiographic study of liposomal mifamurtide (L-MTP-PE) in healthy adult volunteers.
Eur J Clin Pharmacol
; 68(10): 1347-55, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22460239
8.
Evaluation of potential drug interactions with sodium zirconium cyclosilicate: a single-center, open-label, one sequence crossover study in healthy adults.
Clin Kidney J
; 14(7): 1808-1816, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34221388
9.
The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects.
Br J Clin Pharmacol
; 69(1): 23-6, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20078609
10.
Phase 1/2 double-blind, placebo-controlled, dose escalation, safety, and pharmacokinetic study of pagibaximab (BSYX-A110), an antistaphylococcal monoclonal antibody for the prevention of staphylococcal bloodstream infections, in very-low-birth-weight neonates.
Antimicrob Agents Chemother
; 53(7): 2879-86, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19380597
11.
Ocular Distribution of Cyclosporine Following Topical Administration of OTX-101 in New Zealand White Rabbits.
J Ocul Pharmacol Ther
; 35(7): 395-402, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31355703
12.
A phase 1, open-label, single-arm study evaluating the ocular safety of OTX-101 and systemic absorption of cyclosporine in healthy human volunteers.
Clin Ophthalmol
; 13: 591-596, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31040639
13.
Pharmacokinetics, Pharmacodynamics, and Safety of a Long-Acting Human Growth Hormone (MOD-4023) in Healthy Japanese and Caucasian Adults.
Clin Pharmacol Drug Dev
; 7(5): 554-563, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29136343
14.
Pharmacokinetics of Diclofenac and Hydroxypropyl-ß-Cyclodextrin (HPßCD) Following Administration of Injectable HPßCD-Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment.
Clin Pharmacol Drug Dev
; 7(2): 110-122, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29197175
15.
Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes.
Steroids
; 134: 43-52, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29524454
16.
Comparative Bioavailability of Hydroxyprogesterone Caproate Administered via Intramuscular Injection or Subcutaneous Autoinjector in Healthy Postmenopausal Women: A Randomized, Parallel Group, Open-label Study.
Clin Ther
; 39(12): 2345-2354, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191450
17.
Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers.
Clin Pharmacol
; 8: 155-162, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27785111
18.
A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-ß-cyclodextrin.
Clin Pharmacol
; 8: 203-212, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28008289
19.
Pharmacokinetics of the dual melatonin receptor agonist tasimelteon in subjects with hepatic or renal impairment.
J Clin Pharmacol
; 55(5): 525-33, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25450415
20.
Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist.
J Clin Pharmacol
; 55(9): 1004-11, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851638