RESUMO
Potassium comenate and comenic acid exhibit manifest and virtually identical antioxidant activity under conditions of hypoxia with hypercapnia. The effects of these drugs on conditioned reflex training with positive reinforcement differ significantly. Potassium comenate promotes retention of the learning capacity and memory in hypoxic rats at the level of intact control, that is, exhibits a pronounced protective antiamnestic effect, while comenic acid only facilitates training of the conditioned reflex with positive reinforcement.
Assuntos
Antioxidantes/farmacologia , Encéfalo/efeitos dos fármacos , Ácidos Carboxílicos/farmacologia , Hipercapnia/tratamento farmacológico , Hipóxia/tratamento farmacológico , Memória/efeitos dos fármacos , Nootrópicos/farmacologia , Pironas/farmacologia , Animais , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Condicionamento Psicológico/efeitos dos fármacos , Hipercapnia/metabolismo , Hipercapnia/fisiopatologia , Hipóxia/metabolismo , Hipóxia/fisiopatologia , Masculino , Malondialdeído/antagonistas & inibidores , Malondialdeído/metabolismo , Aprendizagem em Labirinto/efeitos dos fármacos , Ratos , Ratos Wistar , Espécies Reativas de Oxigênio/antagonistas & inibidores , Espécies Reativas de Oxigênio/metabolismoRESUMO
The effects of potassium comenate on functional state of CNS in mice and rats were studied in the open-field and hole-board tests under control conditions and after acute exposure to hypoxia-hypercapnia. The effects of potassium comenate on CNS were also studied in rodents subjected to propofol-induced sleep. Preliminary administration of 4 mg/kg potassium comenate for 3 days attenuated the posthypoxic changes in behavioral reactions (emotional anxiety/reactivity). The pronounced stress-protective effect of potassium comenate was observed both on days 1 and 14 after exposure to hypoxia-hypercapnia. Under normal conditions, potassium comenate moderated behavioral reactions and augmented somniferous effect of propofol. We hypothesized that the antihypoxic effect of potassium comenate is determined by its stress-protective and sedative potencies.
Assuntos
Ácidos Carboxílicos/farmacologia , Comportamento Exploratório/efeitos dos fármacos , Hipercapnia/tratamento farmacológico , Hipnóticos e Sedativos/farmacologia , Hipóxia/tratamento farmacológico , Fármacos Neuroprotetores/farmacologia , Pironas/farmacologia , Animais , Ansiedade , Avaliação Pré-Clínica de Medicamentos , Hipercapnia/psicologia , Hipóxia/psicologia , Masculino , Atividade Motora/efeitos dos fármacos , Propofol/farmacologia , Ratos Wistar , Sono/efeitos dos fármacosRESUMO
We studied antioxidant protective effect of comenic acid and potassium comenate in doses of 2, 4, and 8 mg/kg under conditions of oxidative stress in the brain of mice exposed to immobilization stress. Administration of potassium comenate and comenic acid in the above doses for 3 days before stress prevented the development of oxidative processes in the brain of stressed animals. The antioxidant effect of potassium comenate more pronounced.