Detalhe da pesquisa
1.
A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.
Mol Cell
; 67(2): 308-321.e6, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28732206
2.
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Genes Dev
; 29(21): 2231-43, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494712
3.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Nature
; 526(7572): 273-276, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416749
4.
LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.
Blood
; 131(15): 1730-1742, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453291
5.
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Blood
; 131(24): 2661-2669, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29724899
6.
SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
Blood
; 130(24): 2631-2641, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29018079
7.
Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.
Blood
; 136(17): 1983-1988, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575123
8.
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Blood
; 126(22): 2479-83, 2015 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26443624
9.
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Blood
; 124(1): 13-23, 2014 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24764564
10.
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
Blood
; 119(24): 5838-49, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22553314
11.
The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons.
Nucleic Acids Res
; 40(Database issue): D984-91, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22121217
12.
Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.
Blood
; 118(1): 69-79, 2011 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21555743
13.
A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition.
Cancer Discov
; 13(1): 146-169, 2023 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36264143
14.
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Nature
; 442(7104): 818-22, 2006 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16862118
15.
Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism.
Exp Biol Med (Maywood)
; 247(11): 958-971, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35220781
16.
MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.
Cancer Discov
; 12(7): 1804-1823, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35499757
17.
HOXA9 is required for survival in human MLL-rearranged acute leukemias.
Blood
; 113(11): 2375-85, 2009 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19056693
18.
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
; 113(15): 3461-71, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19211936
19.
MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.
Haematologica
; 100(5): e190-3, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25596271
20.
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.
Science
; 367(6477): 586-590, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001657