Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters.
Molecules
; 27(2)2022 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056732
3.
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Bioorg Med Chem Lett
; 29(10): 1182-1186, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926247
4.
Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.
Bioorg Med Chem
; 26(4): 938-944, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28751197
5.
Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor.
J Org Chem
; 81(21): 10256-10265, 2016 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27471910
6.
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Bioorg Med Chem Lett
; 26(11): 2622-6, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27106708
7.
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Bioorg Med Chem Lett
; 25(24): 5767-71, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26546218
8.
Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
Bioorg Med Chem Lett
; 23(23): 6228-33, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157366
9.
Synthesis of stable isotope labeled anacetrapib, its major metabolites and [(14) C]anacetrapib.
J Labelled Comp Radiopharm
; 56(12): 600-8, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24285236
10.
Synthesis of a Complex and Highly Potent PCSK9 Inhibitor.
Org Lett
; 25(27): 5001-5005, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37382389
11.
Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocity.
J Org Chem
; 76(3): 993-6, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21235265
12.
Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
J Org Chem
; 76(19): 7804-15, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21838271
13.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
14.
One-pot iodination of hydroxypyridines.
J Org Chem
; 74(14): 5111-4, 2009 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19485353
15.
Expedient synthesis of 3-alkoxymethyl- and 3-aminomethyl-pyrazolo[3,4-b]pyridines.
J Org Chem
; 74(2): 789-94, 2009 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19067568
16.
Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles.
Org Lett
; 18(24): 6388-6391, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978635
17.
Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
J Med Chem
; 59(24): 11039-11049, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002958
18.
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 58(20): 8154-65, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26397965
19.
Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones.
Org Lett
; 5(21): 3975-8, 2003 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14535757
20.
Effective strategy for the preparation of indolocarbazole aglycons and glycosides: total synthesis of tjipanazoles B, D, E, and I.
Org Lett
; 5(20): 3721-3, 2003 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-14507214