RESUMO
CASE REPORT: The authors report the case of a ten-year-old girl, who had been treated for a malignant germinal tumour five years before, presenting with a leukaemia-like syndrome associating bone pain, liver and spleen nodules and bone marrow involvement. The cyto-pathological analysis showed undifferentiated cells and CD56 and protein S100 were found as the only positive markers. The child received several subsequent lines of chemotherapy and ultimately died of the disease. COMMENTS: Particular cytogenetic abnormalities were observed (iso1q10, iso6p10) and were in favor of an unusual NK cell lymphoma. CONCLUSION: This analysis revealed a XY genotype (testicular feminization syndrome).
Assuntos
Síndrome de Resistência a Andrógenos/genética , Células Matadoras Naturais , Leucemia Linfocítica Crônica de Células B/genética , Leucemia/genética , Neoplasias Ovarianas/genética , Teratoma/genética , Síndrome de Resistência a Andrógenos/diagnóstico , Síndrome de Resistência a Andrógenos/patologia , Medula Óssea/patologia , Antígeno CD56/genética , Transformação Celular Neoplásica/genética , Transformação Celular Neoplásica/patologia , Criança , Feminino , Genótipo , Humanos , Células Matadoras Naturais/patologia , Leucemia/diagnóstico , Leucemia/patologia , Leucemia Linfocítica Crônica de Células B/diagnóstico , Leucemia Linfocítica Crônica de Células B/patologia , Fígado/patologia , Masculino , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/patologia , Proteínas S100/genética , Teratoma/diagnóstico , Teratoma/patologiaRESUMO
Early predictive factors of HIV infection in infants born to HIV infected mothers were carried out to evaluate the roles of immunological parameters for the diagnosis and prognosis of HIV infection. T-lymphocyte subsets and serum immunoglobulins were studied on cord blood in three groups of neonates: 14 infected infants, 29 sero-reverted infants and 31 control neonates. No differences were observed between the three groups. At 3 months, IgG were significantly higher in the infected infants than in sero-reverted infants. After 6 months, CD4 + cell counts, CD4/CD8 ratio were significantly lower in the infected infants and serum IgG, IgA and IgM were significantly higher in the infected group. Antigenemia p24 was detected in 78% of the infected group before 6 months. Total HIV-specific antibody persisted and progressed after 6 months. These data and viral detection appear to be complementary and useful for therapeutic strategies.