Detalhe da pesquisa
1.
Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies.
Biochim Biophys Acta
; 1838(11): 2817-24, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25064156
2.
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries.
Proc Natl Acad Sci U S A
; 109(34): E2248-57, 2012 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843676
3.
Directed evolution for high functional production and stability of a challenging G protein-coupled receptor.
Sci Rep
; 11(1): 8630, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883583
4.
Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase.
ACS Synth Biol
; 10(9): 2396-2408, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34399052
5.
Crystal structure of the human oxytocin receptor.
Sci Adv
; 6(29): eabb5419, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832646
6.
A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins.
Nat Commun
; 10(1): 1830, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31015433
7.
High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.
Nat Struct Mol Biol
; 25(12): 1086-1092, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30455434
8.
Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries.
ACS Chem Biol
; 12(3): 735-745, 2017 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28032980
9.
SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.
PLoS One
; 12(5): e0175842, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28510609
10.
Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts.
Sci Rep
; 6: 21508, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26911446
11.
Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
J Mol Biol
; 428(6): 1272-1289, 2016 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26812208
12.
Stabilizing membrane proteins through protein engineering.
Curr Opin Chem Biol
; 17(3): 427-35, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23639904
13.
Knowledge-based design of a biosensor to quantify localized ERK activation in living cells.
Chem Biol
; 20(6): 847-56, 2013 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23790495
14.
Designed ankyrin repeat proteins (DARPins) as novel isoform-specific intracellular inhibitors of c-Jun N-terminal kinases.
ACS Chem Biol
; 7(8): 1356-66, 2012 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22568706
15.
An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
EMBO J
; 25(21): 5150-8, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17053779