Detalhe da pesquisa
1.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Chembiochem
; 22(12): 2107-2110, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33838082
2.
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Proc Natl Acad Sci U S A
; 110(19): 7922-7, 2013 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620515
3.
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Nat Chem Biol
; 8(11): 890-6, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023262
4.
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Proc Natl Acad Sci U S A
; 107(49): 20980-5, 2010 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078963
5.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Cell Chem Biol
; 28(8): 1158-1168.e13, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705687
6.
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Cancer Cell
; 39(9): 1214-1226.e10, 2021 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375612
7.
Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes.
SLAS Discov
; 25(3): 241-252, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855104
8.
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Cell Chem Biol
; 27(7): 877-887.e14, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32679093
9.
Discovery of thiophene inhibitors of polo-like kinase.
Bioorg Med Chem Lett
; 19(3): 1018-21, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19097784
10.
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Bioorg Med Chem Lett
; 19(3): 1004-8, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19101143
11.
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Bioorg Med Chem Lett
; 19(6): 1694-7, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19237286
12.
Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
PLoS One
; 13(5): e0197082, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29742153
13.
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
PLoS One
; 13(6): e0197372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856759
14.
Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
PLoS One
; 12(1): e0170539, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28085948
15.
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.
J Med Chem
; 59(4): 1556-64, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26769278
16.
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
ACS Med Chem Lett
; 7(2): 134-8, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985287
17.
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.
J Biomol Screen
; 20(6): 810-20, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25755264
18.
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
ACS Med Chem Lett
; 6(5): 491-5, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005520
19.
Reaction coupling between wild-type and disease-associated mutant EZH2.
ACS Chem Biol
; 9(11): 2459-64, 2014 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25154026
20.
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
PLoS One
; 9(12): e111840, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25493630