Detalhe da pesquisa
1.
APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer's disease.
Horm Behav
; 140: 105124, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35101701
2.
Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How.
Neurobiol Dis
; 139: 104811, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32087290
3.
Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease.
Neurobiol Dis
; 114: 120-128, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501530
4.
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.
J Lipid Res
; 58(9): 1733-1755, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389477
5.
Amyloid-ß pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
J Biol Chem
; 289(44): 30538-30555, 2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25217640
6.
APOE-modulated Aß-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective.
J Neurochem
; 133(4): 465-88, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25689586
7.
Levels of soluble apolipoprotein E/amyloid-ß (Aß) complex are reduced and oligomeric Aß increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
J Biol Chem
; 288(8): 5914-26, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23293020
8.
Human APOE4 increases microglia reactivity at Aß plaques in a mouse model of Aß deposition.
J Neuroinflammation
; 11: 111, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948358
9.
APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-ß42 Levels in Non-Hyperlipidemic Mice.
J Alzheimers Dis
; 97(4): 1629-1639, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306049
10.
Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy.
Front Endocrinol (Lausanne)
; 15: 1374825, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742194
11.
Differential regulation of amyloid-ß endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
J Biol Chem
; 287(53): 44593-601, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23132858
12.
APOE4-specific changes in Aß accumulation in a new transgenic mouse model of Alzheimer disease.
J Biol Chem
; 287(50): 41774-86, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23060451
13.
Preferential interactions between ApoE-containing lipoproteins and Aß revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.
Biochim Biophys Acta
; 1821(2): 295-302, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22138302
14.
Role of estrogen in women's Alzheimer's disease risk as modified by APOE.
J Neuroendocrinol
; 35(2): e13209, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36420620
15.
APOE genotype and sex modulate Alzheimer's disease pathology in aged EFAD transgenic mice.
Front Aging Neurosci
; 15: 1279343, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38020764
16.
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice.
Alzheimers Res Ther
; 15(1): 181, 2023 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37858252
17.
Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation.
Neurotherapeutics
; 20(4): 1120-1137, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37157042
18.
A novel apoE-mimetic increases brain apoE levels, reduces Aß pathology and improves memory when treated before onset of pathology in male mice that express APOE3.
Alzheimers Res Ther
; 15(1): 216, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38102668
19.
APOE genotype alters glial activation and loss of synaptic markers in mice.
Glia
; 60(4): 559-69, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22228589
20.
The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha.
Neurobiol Aging
; 112: 74-86, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051676