Detalhe da pesquisa
1.
Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells.
PLoS Pathog
; 16(8): e1008845, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866210
2.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
3.
Data standards in drug discovery: A long way to go.
Drug Discov Today
; 29(2): 103879, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216119
4.
Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity.
Oncotarget
; 13: 332-346, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178190
5.
AI-based language models powering drug discovery and development.
Drug Discov Today
; 26(11): 2593-2607, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34216835
6.
Informing selection of drugs for COVID-19 treatment through adverse events analysis.
Sci Rep
; 11(1): 14022, 2021 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34234253
7.
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.
Sci Signal
; 14(694)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344832
8.
An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication.
Genomics Proteomics Bioinformatics
; 19(1): 108-122, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33610792
9.
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells.
SLAS Discov
; 25(3): 265-276, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31658853
10.
Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Mol Cancer Ther
; 19(1): 52-62, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562255
11.
Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline.
Drug Discov Today
; 24(1): 26-30, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30071313
12.
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
J Med Chem
; 61(11): 4883-4903, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29767973
13.
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Cancer Cell
; 34(6): 939-953.e9, 2018 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30472020
14.
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.
Clin Transl Sci
; 11(5): 461-470, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29877628
15.
RNAi High-Throughput Screening of Single- and Multi-Cell-Type Tumor Spheroids: A Comprehensive Analysis in Two and Three Dimensions.
SLAS Discov
; 22(5): 525-536, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28277887
16.
Exploring Drug Dosing Regimens In Vitro Using Real-Time 3D Spheroid Tumor Growth Assays.
SLAS Discov
; 22(5): 537-546, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28298153
17.
A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth.
SLAS Discov
; 22(5): 494-506, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346091
18.
PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.
Cancer Discov
; 7(8): 884-899, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446439
19.
Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122].
Genomics Proteomics Bioinformatics
; 20(4): 808-809, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669818
20.
Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors.
ACS Chem Biol
; 11(3): 734-41, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26428393