1.
Org Biomol Chem
; 13(32): 8642-6, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26204921
RESUMO
Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of aberrant, helix-mediated protein-protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mcl-1-Bak-BH3 PPI through effective mimicry of key residues on opposing faces of the Bak-BH3 α-helix.