RESUMO
Early in the course of myeloblastic leukemia a patient concurrently developed febrile neutrophilic dermatosis and sterile acute myositis. The dermatitis and myositis were unresponsive to antibiotic therapy but remitted within a few days of institution of steroid treatment. The patient died of myocardial infarction. At autopsy the dermis was normal. Previously effected muscles were scarred. The overlying fascia and subcutaneous septa were fibrotically thickened. In addition, segmental acute aortitis was detected. Acute myositis and aortitis may reflect further organ manifestations of the Sweet's reactivity pattern. It is proposed that Sweet's myositis and dermatitis may evolve into a fibrosing myositis and panniculitis.
Assuntos
Leucemia Mieloide Aguda/complicações , Miosite/patologia , Síndrome de Sweet/patologia , Doença Aguda , Feminino , Fibrose/patologia , Humanos , Pessoa de Meia-Idade , Miosite/etiologia , Paniculite/patologia , Síndrome de Sweet/etiologiaRESUMO
PURPOSE: The aim of this work was to detect nuclear parameters related to the prognosis of patients with stage III, IV or DS neuroblastomas. METHODS: Histological sections of 25 operation specimens obtained from children with advanced-stage neuroblastomas were subjected to computer-assisted image analysis. Statistical relationships between nuclear descriptors of the tumor cells and patients' clinical outcome were determined. RESULTS: The coefficient of variability of the mean nuclear area the mean nuclear elongation factor, and the mean nuclear averaged Feret diameter of the neuroblastoma cells were ascertained to be discriminators separating high-grade from low-grade tumors. CONCLUSIONS: The histomorphometrically gauged nuclear parameters may help oncologists to assess the prognosis of patients with advanced-stage neuroblastoma.
Assuntos
Neoplasias das Glândulas Suprarrenais/mortalidade , Neoplasias das Glândulas Suprarrenais/patologia , Processamento de Imagem Assistida por Computador/normas , Neuroblastoma/mortalidade , Neuroblastoma/patologia , Fatores Etários , Criança , Pré-Escolar , Intervalo Livre de Doença , Feminino , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Lactente , Recém-Nascido , Israel/epidemiologia , Modelos Logísticos , Masculino , Neoplasias do Mediastino/mortalidade , Neoplasias do Mediastino/patologia , Neoplasias Pélvicas/mortalidade , Neoplasias Pélvicas/patologia , Valor Preditivo dos Testes , Prognóstico , Neoplasias Retroperitoneais/mortalidade , Neoplasias Retroperitoneais/patologia , Análise de SobrevidaRESUMO
The salivary composition and flow rate of 78 patients with primary affective disorders and of 49 healthy volunteers were examined. The former were divided into two groups: Group 1--57 patients receiving lithium carbonate and psychoactive drugs, and Group 2--21 patients receiving psychoactive drugs only. A significant correlation between salivary and serum lithium was found in patients on chronic lithium therapy. Significantly reduced salivary flow rates and elevated potassium, calcium, magnesium and IgA concentrations were found in all the patients as compared with those of the healthy volunteers. Salivary sodium concentrations were significantly elevated in patients on lithium carbonate as compared with the levels in patients on psychoactive drugs only. These results indicate that changes in salivary gland function may occur in patients with primary affective disorders and in those receiving drug treatment. The use of saliva analysis for monitoring lithium dosage is recommended.