Detalhe da pesquisa
1.
Studying Structure and Functions of Nucleosomes with Atomic Force Microscopy.
Biochemistry (Mosc)
; 89(4): 674-687, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38831504
2.
A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates.
Nucleic Acids Res
; 50(19): 10817-10838, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36243979
3.
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279210
4.
New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
Molecules
; 29(3)2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38338326
5.
Methods for Assessment of Nucleotide Excision Repair Efficiency.
Biochemistry (Mosc)
; 88(11): 1844-1856, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105203
6.
Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach.
Int J Mol Sci
; 24(9)2023 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37175662
7.
Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing.
Int J Mol Sci
; 24(23)2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069121
8.
Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.
Int J Mol Sci
; 24(6)2023 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982848
9.
Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.
Int J Mol Sci
; 24(4)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835244
10.
New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298106
11.
Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor.
Int J Mol Sci
; 24(6)2023 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982223
12.
Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
Bioorg Med Chem Lett
; 73: 128909, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35907608
13.
Study of Interaction of the PARP Family DNA-Dependent Proteins with Nucleosomes Containing DNA Intermediates of the Initial Stages of BER Process.
Biochemistry (Mosc)
; 87(4): 331-345, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35527371
14.
Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases.
Biochemistry (Mosc)
; 87(Suppl 1): S32-S0, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-35501985
15.
Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1.
Biochemistry (Mosc)
; 87(8): 823-831, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36171646
16.
Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions.
Int J Mol Sci
; 23(22)2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430551
17.
FUS Microphase Separation: Regulation by Nucleic Acid Polymers and DNA Repair Proteins.
Int J Mol Sci
; 23(21)2022 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361989
18.
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
Molecules
; 27(11)2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684313
19.
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Molecules
; 27(8)2022 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458631
20.
The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Molecules
; 28(1)2022 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615517