Detalhe da pesquisa
1.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature
; 600(7887): 153-157, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819673
2.
Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature
; 600(7887): 148-152, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819665
3.
Heparin is essential for optimal cell signaling by FGF21 and for regulation of ßKlotho cellular stability.
Proc Natl Acad Sci U S A
; 120(7): e2219128120, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36745784
4.
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc Natl Acad Sci U S A
; 120(13): e2300054120, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36943885
5.
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell
; 138(3): 514-24, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19665973
6.
Structures of ß-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature
; 553(7689): 501-505, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342135
7.
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol Cell
; 57(1): 191-201, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25544564
8.
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.
Proc Natl Acad Sci U S A
; 117(50): 31800-31807, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33257569
9.
Structures of ligand-occupied ß-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc Natl Acad Sci U S A
; 116(16): 7819-7824, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30944224
10.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Proc Natl Acad Sci U S A
; 115(33): 8340-8345, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30061385
11.
Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.
Proc Natl Acad Sci U S A
; 113(33): E4784-93, 2016 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27482095
12.
Augmentor α and ß (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Proc Natl Acad Sci U S A
; 112(52): 15862-7, 2015 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26630010
13.
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.
Proc Natl Acad Sci U S A
; 111(5): 1772-7, 2014 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24449920
14.
The docking protein FRS2α is a critical regulator of VEGF receptors signaling.
Proc Natl Acad Sci U S A
; 111(15): 5514-9, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24706887
15.
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc Natl Acad Sci U S A
; 110(44): 17832-7, 2013 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24127596
16.
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.
Proc Natl Acad Sci U S A
; 109(12): 4419-24, 2012 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22371560
17.
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc Natl Acad Sci U S A
; 107(7): 2866-71, 2010 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133753
18.
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
Stem Cells
; 28(9): 1661-73, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20652960
19.
Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.
Mol Cell Biol
; 27(19): 6903-12, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17682060
20.
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Mol Cell Biol
; 24(13): 5657-66, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15199124