Detalhe da pesquisa
1.
Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis.
RNA
; 28(2): 227-238, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34815358
2.
Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
J Am Chem Soc
; 143(2): 623-627, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33411531
3.
High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
J Am Chem Soc
; 142(1): 33-37, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31841327
4.
Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J Am Chem Soc
; 140(42): 13542-13545, 2018 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30285435
5.
How the glycosyltransferase OGT catalyzes amide bond cleavage.
Nat Chem Biol
; 12(11): 899-901, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618188
6.
The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.
J Am Chem Soc
; 139(48): 17221-17224, 2017 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29135241
7.
Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Nature
; 469(7331): 564-7, 2011 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21240259
8.
Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
Proc Natl Acad Sci U S A
; 111(13): 4982-7, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24639492
9.
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Bioorg Med Chem
; 23(17): 5483-8, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275681
10.
Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat Chem Biol
; 8(12): 966-8, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103939
11.
Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1.
bioRxiv
; 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370847
12.
A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.
Nat Chem Biol
; 8(1): 72-7, 2011 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22082911
13.
A case of hyperlysinemia identified by urine newborn screening.
JIMD Rep
; 64(6): 440-445, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37927488
14.
Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations.
ACS Chem Biol
; 17(12): 3290-3297, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469692
15.
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
Open Biol
; 12(9): 220179, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36128717
16.
Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.
ACS Chem Biol
; 15(8): 2041-2047, 2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633484
17.
Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response.
Cell Signal
; 29: 78-83, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27760376
18.
Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.
ACS Chem Biol
; 10(1): 257-61, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25551253
19.
A small molecule that inhibits OGT activity in cells.
ACS Chem Biol
; 10(6): 1392-7, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25751766
20.
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science
; 342(6163): 1235-9, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24311690