RESUMO
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
Assuntos
Fabaceae/química , Terpenos/química , Terpenos/farmacologia , Animais , Humanos , Extratos Vegetais/química , Extratos Vegetais/farmacologiaRESUMO
Essential oils from leaves and stems of Eperua duckeana Cowan (Fabaceae) were extracted by hydrodistillation and analyzed by GC/FID and GC/MS. Sixteen and nineteen components were identified by comparison by their retention indices (RI) and mass spectra. The major components identified in leaves were (E)-caryophyllene (31.8 percent), caryophyllene oxide (25.7 percent) and alpha- humulene (4.4 percent), and stems (E)-caryophyllene (34.5 percent) and germacrene D (25.9 percent). The stems oil essential showed high cytotoxicity against tumor cell lines of leukemia (HL-60). This is the first report regarding the essential oil composition and citotoxicy activity of the essential oil of Eperua duckeana Cowan...
Óleos essenciais de folhas e galhos de Eperua duckeana Cowan (Fabaceae) foram extraídos por hidrodestilação e analisados por CG-DIC e CG-EM. Dezesseis e dezenove componentes foram identificados por comparação com seus índices de retenção (IR) e espectros de massas. Os componentes principais identificados nas folhas foram o (E)-cariofileno (31,8 por cento), óxido de cariofileno (25,7 por cento) e o alfa- humuleno (4,4 por cento), nos galhos (E)-cariofileno (34,5 por cento) e o D-germacreno (25,9 por cento). O óleo essencial dos galhos mostrou alta citoxicidade contra linhagens de células de leucemia (HL-60). Esse é a primeiro relato abordando a composição dos óleos essenciais e a atividade citotóxica do óleo essencial de Eperua duckeana Cowan...