Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother
; 57(2): 804-10, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23183437
3.
Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease.
Bioorg Med Chem Lett
; 22(2): 1095-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22189140
4.
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrob Agents Chemother
; 55(6): 2905-15, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464257
5.
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.
Antimicrob Agents Chemother
; 55(4): 1366-76, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245449
6.
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
J Mol Biol
; 363(3): 635-47, 2006 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979654
7.
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
J Med Chem
; 60(3): 1000-1017, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075591
8.
Characterization of protein-protein interactions by isothermal titration calorimetry.
Methods Mol Biol
; 1278: 183-204, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25859950
9.
Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
Curr Protein Pept Sci
; 5(1): 1-8, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14965316
10.
Characterization of protein-protein interactions by isothermal titration calorimetry.
Methods Mol Biol
; 261: 35-54, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15064448
11.
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
J Med Chem
; 57(5): 1893-901, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24144213
12.
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.
J Mol Biol
; 400(3): 354-78, 2010 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20451531
13.
The linkage between protein folding and functional cooperativity: two sides of the same coin?
Annu Rev Biophys Biomol Struct
; 31: 235-56, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-11988469
14.
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.
Biochemistry
; 43(17): 4906-12, 2004 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15109248
15.
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature
; 420(6916): 678-82, 2002 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12478295