1.
J Neuroimmunol
; 355: 577552, 2021 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33845282
RESUMO
A 43 year-old male presented with a relapsing and progressive systemic inflammatory disorder with central nervous system (CNS) involvement. After a two years follow up, he was diagnosed with hemophagocytic lymphohistiocytosis (HLH), based on clinical, laboratory and radiological findings. Treatment was started with anakinra, a recombinant humanised interleukin-1 (IL-1) receptor antagonist. Clinical response was good. Laboratory and radiological findings showed no disease activity throughout a five years follow-up period. Several immunosuppressive agents have been used in HLH without any good outcomes. This is the first case report of HLH with CNS involvement responsive to chronic treatment with anakinra.
Assuntos
Encéfalo/diagnóstico por imagem , Proteína Antagonista do Receptor de Interleucina 1/administração & dosagem , Linfo-Histiocitose Hemofagocítica/diagnóstico por imagem , Linfo-Histiocitose Hemofagocítica/tratamento farmacológico , Nervos Espinhais/diagnóstico por imagem , Adulto , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Seguimentos , Humanos , Proteína Antagonista do Receptor de Interleucina 1/metabolismo , Linfo-Histiocitose Hemofagocítica/metabolismo , Masculino , Receptores de Interleucina-1/agonistas , Receptores de Interleucina-1/metabolismo , Recidiva , Nervos Espinhais/efeitos dos fármacos , Nervos Espinhais/metabolismo , Resultado do Tratamento
2.
J Clin Rheumatol
; 20(1): 45-6, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24356482