Detalhe da pesquisa
1.
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophys J
; 108(6): 1400-1413, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809253
2.
Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
J Mol Cell Cardiol
; 85: 71-8, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986146
3.
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1ß.
Exp Physiol
; 98(2): 462-72, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22848083
4.
Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
J Pharmacol Exp Ther
; 342(2): 441-52, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22573844
5.
Structural insights into the role of DNA-PK as a master regulator in NHEJ.
Genome Instab Dis
; 2(4): 195-210, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34723130
6.
Lipid regulation of hERG1 channel function.
Nat Commun
; 12(1): 1409, 2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33658490
7.
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.
Prog Biophys Mol Biol
; 163: 87-108, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035590
8.
In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".
J Mol Cell Cardiol
; 87: 192-3, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26299838
9.
Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.
Circ Res
; 103(12): 1483-91, 2008 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18948620
10.
Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.
Biophys J
; 96(9): 3600-10, 2009 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19413965
11.
Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia.
Mol Cell Biol
; 23(6): 1856-62, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612061
12.
Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees C.
Heart Rhythm
; 2(8): 860-6, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16051125
13.
[K(+)](o)-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype.
Cardiovasc Res
; 57(3): 642-50, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12618226
14.
Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells.
Cardiovasc Res
; 61(2): 268-77, 2004 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14736543
15.
Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-ß.
Circ Arrhythm Electrophysiol
; 8(2): 420-8, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25648353
16.
iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin.
Am J Physiol Heart Circ Physiol
; 295(3): H1122-H1131, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621856