Detalhe da pesquisa
1.
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso.
Antimicrob Agents Chemother
; 68(4): e0153423, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38411062
2.
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria.
Int J Mol Sci
; 25(8)2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38673995
3.
Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.
Bioorg Chem
; 137: 106587, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163812
4.
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
Bioorg Med Chem
; 39: 116159, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33895706
5.
Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-ß-carboline-4-aminoquinoline conjugates.
Bioorg Med Chem Lett
; 30(2): 126810, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740250
6.
Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation.
Bioorg Chem
; 88: 102912, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30991190
7.
Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1234: 124030, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309043
8.
Quinoline-based heterocyclic hydrazones: Design, synthesis, anti-plasmodial assessment, and mechanistic insights.
Chem Biol Drug Des
; 101(4): 829-836, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36418231
9.
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents.
Eur J Med Chem
; 248: 115055, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36621136
10.
Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach.
RSC Med Chem
; 14(12): 2768-2781, 2023 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38107179
11.
Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.
Future Med Chem
; 14(24): 1865-1880, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36622669
12.
Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.
ACS Chem Biol
; 17(3): 576-589, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35262340
13.
Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.
Eur J Med Chem
; 236: 114324, 2022 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35390711
14.
Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives.
RSC Med Chem
; 12(6): 970-981, 2021 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34223162
15.
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.
Nat Commun
; 12(1): 6714, 2021 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795281
16.
Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights.
ACS Med Chem Lett
; 11(2): 154-161, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071682
17.
Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation.
Chem Biol Drug Des
; 96(6): 1355-1361, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32515142
18.
Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials.
Future Med Chem
; 12(3): 193-205, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31802710
19.
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
mBio
; 11(1)2020 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992618
20.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Nat Commun
; 8: 14574, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262680