Detalhe da pesquisa
1.
Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency.
J Biol Chem
; 289(20): 14392-8, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24692552
2.
Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements.
Mol Ther Methods Clin Dev
; 32(1): 101217, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496304
3.
PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper.
AAPS J
; 25(5): 78, 2023 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523051
4.
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper.
Mol Ther Methods Clin Dev
; 26: 471-494, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092368
5.
2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccine Assays; Immunogenicity of Biotherapeutics and Novel Modalities; Integrated Summary of Immunogenicity Harmonization).
Bioanalysis
; 14(11): 737-793, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578991
6.
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases.
MAbs
; 8(1): 141-9, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26390837
7.
COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia.
Leukemia
; 33(3): 805-808, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206306