Detalhe da pesquisa
1.
Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.
Am J Physiol Renal Physiol
; 315(3): F537-F546, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29767557
2.
Fluid shear stress-induced TGF-ß/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Cell Mol Life Sci
; 74(12): 2283-2298, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28168444
3.
Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.
Am J Physiol Renal Physiol
; 312(4): F806-F817, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28148532
4.
STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.
Kidney Int
; 91(3): 575-586, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28104302
5.
Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context.
J Am Soc Nephrol
; 27(12): 3530-3538, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27493259
6.
Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease.
J Am Soc Nephrol
; 27(10): 3079-3092, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26940098
7.
Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.
J Am Soc Nephrol
; 27(12): 3589-3599, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020852
8.
Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.
J Am Soc Nephrol
; 26(6): 1322-33, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361818
9.
Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.
J Transl Med
; 13: 103, 2015 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25888842
10.
Cyst expansion and regression in a mouse model of polycystic kidney disease.
Kidney Int
; 83(6): 1099-108, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23466997
11.
Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease.
J Am Soc Nephrol
; 23(5): 842-53, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22343118
12.
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Front Mol Biosci
; 10: 1058825, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36743216
13.
Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease.
iScience
; 26(11): 108278, 2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38026227
14.
Altered Hippo signalling in polycystic kidney disease.
J Pathol
; 224(1): 133-42, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21381034
15.
Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Clin J Am Soc Nephrol
; 17(4): 507-517, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314480
16.
Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
Am J Physiol Renal Physiol
; 300(5): F1193-202, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21345977
17.
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways.
Hum Mol Genet
; 18(14): 2532-42, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19401297
18.
Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
J Pathol
; 222(1): 21-31, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20549648
19.
Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective.
Sci Rep
; 10(1): 1672, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32015419
20.
Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.
EBioMedicine
; 51: 102585, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879244