Detalhe da pesquisa
1.
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Acta Neuropathol
; 141(3): 359-381, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496840
2.
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
J Biol Chem
; 294(29): 11276-11285, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167792
3.
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
J Biol Chem
; 286(46): 39794-803, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21868380
4.
Deletion of Abi3/Gngt2 influences age-progressive amyloid ß and tau pathologies in distinctive ways.
Alzheimers Res Ther
; 14(1): 104, 2022 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897046
5.
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimers Res Ther
; 12(1): 61, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32430033
6.
Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Alzheimers Res Ther
; 11(1): 16, 2019 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30711010
7.
And four equals one: presenilin takes the gamma-secretase role by itself.
Proc Natl Acad Sci U S A
; 107(50): 21236-7, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135249
8.
High-affinity interactions and signal transduction between Aß oligomers and TREM2.
EMBO Mol Med
; 10(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341064
9.
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
EMBO Mol Med
; 9(7): 950-966, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28539479
10.
The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
Cell Signal
; 17(4): 437-45, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15601622
11.
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
PLoS One
; 10(12): e0144758, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26678856
12.
A nuclear function for the presenilin 1 neuronal partner NPRAP/δ-catenin.
J Alzheimers Dis
; 27(2): 307-16, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21811021