Detalhe da pesquisa
1.
New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task.
Behav Pharmacol
; 30(4): 351-357, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30489342
2.
Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces.
J Chem Inf Model
; 54(12): 3404-16, 2014 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25420075
3.
Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.
ACS Chem Neurosci
; 12(14): 2679-2692, 2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34242002
4.
Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.
Bioorg Med Chem Lett
; 20(22): 6667-70, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20880707
5.
Preparation and affinity profile of novel nicotinic ligands.
Bioorg Med Chem Lett
; 18(6): 2188-93, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18262785
6.
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
Bioorg Med Chem
; 16(23): 9948-56, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18980844
7.
Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons.
Neuropharmacology
; 53(1): 134-44, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544457
8.
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
J Med Chem
; 50(13): 3153-7, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17552506
9.
S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures.
Eur J Pharmacol
; 561(1-3): 23-31, 2007 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331496
10.
Neuroprotection: Present and future.
Therapie
; 62(6): 473-6, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316012
11.
Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.
Eur J Pharmacol
; 803: 11-23, 2017 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336400
12.
In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist.
Eur J Pharmacol
; 803: 1-10, 2017 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28315340
13.
Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.
PLoS One
; 12(9): e0184429, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28886144
14.
Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.
ACS Chem Neurosci
; 7(3): 378-90, 2016 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26771108
15.
Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies.
J Med Chem
; 48(4): 1282-6, 2005 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15715499
16.
In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176).
Eur J Pharmacol
; 511(2-3): 127-36, 2005 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15792780
17.
[Synaptic plasticity and neuropathology: new approaches in drug discovery]. / Plasticité cérébrale et neuropathologies: nouvelles voies pour le médicament.
Med Sci (Paris)
; 21(1): 104-9, 2005 Jan.
Artigo
em Francês
| MEDLINE | ID: mdl-15639031
18.
Cognition enhancing or neuroprotective compounds for the treatment of cognitive disorders: why? when? which?
Exp Gerontol
; 38(1-2): 119-28, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12543269
19.
S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.
Neurosci Lett
; 361(1-3): 120-3, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15135908
20.
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.
Eur J Med Chem
; 38(1): 1-11, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12593911