Detalhe da pesquisa
1.
P2X7 receptor antagonists for the treatment of systemic inflammatory disorders.
Prog Med Chem
; 59: 63-99, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32362329
2.
The evolution of P2X7 antagonists with a focus on CNS indications.
Bioorg Med Chem Lett
; 26(16): 3838-45, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27426304
3.
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.
Bioorg Med Chem Lett
; 26(2): 257-261, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707399
4.
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.
Bioorg Med Chem Lett
; 25(16): 3157-63, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099534
5.
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
J Pharmacol Exp Ther
; 351(3): 628-41, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25271258
6.
P2X7 antagonists as potential therapeutic agents for the treatment of CNS disorders.
Prog Med Chem
; 53: 65-100, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418608
7.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem
; 66(4): 2877-2892, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757100
8.
Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
J Org Chem
; 75(13): 4463-71, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20536151
9.
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.
Bioorg Med Chem Lett
; 20(2): 469-73, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969459
10.
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(21): 6226-30, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843691
11.
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 20(9): 2755-60, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20382018
12.
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorg Med Chem Lett
; 20(14): 4210-4, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561786
13.
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
J Med Chem
; 63(17): 9181-9196, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787105
14.
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
ACS Med Chem Lett
; 10(3): 261-266, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891123
15.
In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
Eur J Pharmacol
; 587(1-3): 141-6, 2008 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18499098
16.
2-Aryloxymethylmorpholine histamine H(3) antagonists.
Bioorg Med Chem Lett
; 18(21): 5796-9, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922693
17.
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 18(1): 39-43, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18060777
18.
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Bioorg Med Chem
; 16(6): 2968-73, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18249544
19.
Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia.
Neuropsychopharmacology
; 43(13): 2586-2596, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30026598
20.
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
J Med Chem
; 61(1): 207-223, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211470