RESUMO
Background: The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for "suspect screening" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide. Results: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA's CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101). Conclusions: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the "one substance, one assessment" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/). Supplementary Information: The online version contains supplementary material available at 10.1186/s12302-022-00680-6.
RESUMO
A large number of anthropogenic trace contaminants such as pharmaceuticals, their human metabolites and further transformation products (TPs) enter wastewater treatment plants on a daily basis. A mixture of known, expected, and unknown molecules are discharged into the receiving aquatic environment because only partial elimination occurs for many of these chemicals during physical, biological and chemical treatment processes. In this study, an array of LC-MS methods from three collaborating laboratories was applied to detect and identify anthropogenic trace contaminants and their TPs in different waters. Starting with theoretical predictions of TPs, an efficient workflow using the combination of target, suspected-target and non-target strategies for the identification of these TPs in the environment was developed. These techniques and strategies were applied to study anti-hypertensive drugs from the sartan group (i.e., candesartan, eprosartan, irbesartan, olmesartan, and valsartan). Degradation experiments were performed in lab-scale wastewater treatment plants, and a screening workflow including an inter-laboratory approach was used for the identification of transformation products in the effluent samples. Subsequently, newly identified compounds were successfully analyzed in effluents of real wastewater treatment plants and river waters.
Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II/análise , Cromatografia Líquida/métodos , Monitoramento Ambiental/métodos , Espectrometria de Massas/métodos , Águas Residuárias/análise , Poluentes Químicos da Água/análise , Bloqueadores do Receptor Tipo 1 de Angiotensina II/química , Benzimidazóis/análise , Benzimidazóis/química , Compostos de Bifenilo/análise , Compostos de Bifenilo/química , Monitoramento Ambiental/normas , Imidazóis/análise , Imidazóis/química , Irbesartana , Laboratórios/normas , Tetrazóis/análise , Tetrazóis/química , Águas Residuárias/química , Poluentes Químicos da Água/química , Purificação da Água , Fluxo de TrabalhoRESUMO
An increasing number of organic micropollutants (OMP) is detected in anthropogenically influenced water cycles. Source control and effective natural and technical barriers are essential to maintain a high quality of drinking water resources under these circumstances. Based on the literature and our own research this study proposes a limited number of OMP that can serve as indicator substances for the major sources of OMP, such as wastewater treatment plants, agriculture and surface runoff. Furthermore functional indicators are proposed that allow assessment of the proper function of natural and technical barriers in the aquatic environment, namely conventional municipal wastewater treatment, advanced treatment (ozonation, activated carbon), bank filtration and soil aquifer treatment as well as self-purification in surface water. These indicator substances include the artificial sweetener acesulfame, the anti-inflammatory drug ibuprofen, the anticonvulsant carbamazepine, the corrosion inhibitor benzotriazole and the herbicide mecoprop among others. The chemical indicator substances are intended to support comparisons between watersheds and technical and natural processes independent of specific water cycles and to reduce efforts and costs of chemical analyses without losing essential information.
Assuntos
Indicadores e Reagentes/química , Compostos Orgânicos/análise , Águas Residuárias/química , Ciclo Hidrológico , Poluentes Químicos da Água/análise , Ácido 2-Metil-4-clorofenoxiacético/análogos & derivados , Ácido 2-Metil-4-clorofenoxiacético/química , Carbamazepina/química , Carvão Vegetal/química , Filtração , Tiazinas/química , Triazóis/químicaRESUMO
Pharmaceuticals and other anthropogenic trace contaminants reach wastewaters and are often not satisfactorily eliminated in sewage treatment plants. These contaminants and/or their degradation products may reach surface waters, thus influencing aquatic life. In this study, the behavior of five different antihypertonic pharmaceuticals from the sartan group (candesartan, eprosartan, irbesartan, olmesartan and valsartan) is investigated in lab-scale sewage plants. The elimination of the substances with related structures varied broadly from 17 % for olmesartan up to 96 % for valsartan. Monitoring data for these drugs in wastewater effluents of six different sewage treatment plants (STPs) in Bavaria, and at eight rivers, showed median concentrations for, e.g. valsartan of 1.1 and 0.13 µg L(-1), respectively. Predicted environmental concentrations (PEC) were calculated and are mostly consistent with the measured environmental concentrations (MEC). The selected sartans and the mixture of the five sartans showed no ecotoxic effects on aquatic organisms in relevant concentrations. Nevertheless, the occurrence of pharmaceuticals in the environment should be reduced to minimize the risk of their distribution in surface waters, ground waters and bank filtrates used for drinking water.
Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II/análise , Anti-Hipertensivos/análise , Monitoramento Ambiental/estatística & dados numéricos , Rios/química , Eliminação de Resíduos Líquidos/métodos , Águas Residuárias/química , Poluentes Químicos da Água/análise , Acrilatos/análise , Acrilatos/química , Bloqueadores do Receptor Tipo 1 de Angiotensina II/química , Anti-Hipertensivos/química , Benzimidazóis/análise , Benzimidazóis/química , Biodegradação Ambiental , Compostos de Bifenilo/análise , Compostos de Bifenilo/química , Cromatografia Líquida , Monitoramento Ambiental/métodos , Alemanha , Imidazóis/análise , Imidazóis/química , Irbesartana , Espectrometria de Massas , Estrutura Molecular , Tetrazóis/análise , Tetrazóis/química , Tiofenos/análise , Tiofenos/química , Valina/análogos & derivados , Valina/análise , Valina/química , Valsartana , Poluentes Químicos da Água/químicaRESUMO
Fragrances are used in a wide array of everyday products and enter the aquatic environment via wastewater. While several musk compounds have been studied in detail, little is known about the occurrence and fate of other fragrances. We selected 16 fragrance compounds and scrutinized their presence in Bavarian sewage treatment plants (STP) influents and effluents and discussed their ecological risks for the receiving surface waters. Moreover, we followed their concentrations along the path in one STP by corresponding time-related water sampling and derived the respective elimination rates in the purification process. Six fragrance substances (OTNE, HHCB, lilial, acetyl cedrene, menthol, and, in some grab samples, also methyl-dihydrojasmonate) could be detected in the effluents of the investigated sewage treatment plants. The other fragrances under scrutiny were only found in the inflow and were eliminated in the purification process. Only OTNE and HHCB were found in the receiving surface waters of the STP in congruent concentrations, which exceeded the preliminary derived environmental thresholds by a factor of 1.15 and 1.12, respectively, indicating potential risks. OTNE was also detected in similar concentration ranges as HHCB in muscles and livers of fish from surface waters and from ponds that are supplied with purified wastewater. The findings show that some fragrance compounds undergo high elimination rates, whereas others-not only musks-are present in receiving surface water and biota and may present a risk to local aquatic biota. Hence, our results suggest that the fate and potential effects of fragrance compounds in the aquatic environment deserve more attention.
Assuntos
Monitoramento Ambiental , Perfumes/análise , Esgotos/química , Poluentes Químicos da Água/análise , Purificação da Água , Animais , Benzopiranos/análise , Carpas , Cromatografia Gasosa-Espectrometria de Massas , Alemanha , Músculo Esquelético/química , Hidrocarbonetos Policíclicos Aromáticos/análise , Estudos Retrospectivos , Medição de Risco , Espectrometria de Massas em TandemRESUMO
To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface water and bank filtrate was developed. Carbamazepine known as very stable in the aquatic environment was analyzed as anthropogenic marker in parallel. Furthermore, the removal of ritalinic acid was studied in a sewage treatment plant using an activated sludge system during a field study and in lab-scale plants. In good agreement between lab-scale and field studies a low removal rate of 13% and 23%, respectively, was determined. As a consequence, the concentration of ritalinic acid in the wastewater effluents were in the range of <50-170 ngL(-1) which corresponds to a mean specific load per capita of 17.7 µgd(-1). Ritalinic acid has further been detected in German rivers at concentrations of 4-23 ngL(-1) and in bank filtrate samples in 100-850 m distance from the river up to 5 ngL(-1) demonstrating the widespread occurrence of this stable metabolite in the aquatic environment. A comparison to available sales data shows that a significant amount of methylphenidate applied can be found in waters as ritalinic acid.
Assuntos
Estimulantes do Sistema Nervoso Central/análise , Água Doce/química , Metilfenidato/análogos & derivados , Carbamazepina/análise , Estimulantes do Sistema Nervoso Central/química , Monitoramento Ambiental , Metilfenidato/análise , Metilfenidato/química , Modelos Químicos , Eliminação de Resíduos LíquidosRESUMO
Although various single-concentration measurements of the pharmaceutical diclofenac are available in literature, detailed information on the mass flux in the aquatic environment is often missing. Therefore, the overall load of diclofenac was obtained by recording each concentration in nine effluents of sewage treatment plants (STP) and at three river sites located in the area of the river Main (Germany) over a time period of six weeks. In STP effluents, concentrations of up to 2200 ng/L were obtained. In combination with flow rates and connected population an average specific load per capita and day of 0.28 mg (+/-0.11 mg) diclofenac reaches the receiving water course. This average specific load per capita is an expressive parameter to assess main diclofenac exposure to the aquatic environment avoiding uncertainties of estimated data commonly used in exposure assessment. Accordingly, predicted environmental concentrations (PEC) of 140 ng/L for a realistic worst case scenario and 2 to 52 ng/L based on water quality modeling were derived. Since concentrations of up to 140 ng/L were observed in surface water, the obtained PEC is in perfect agreement with measured concentrations. Hence, comparing the PEC with published predicted no effect concentrations (PNEC), chronic adverse effects in fish populations may occur.
Assuntos
Diclofenaco/análise , Esgotos/química , Poluentes Químicos da Água/análise , Água/análise , Animais , Exposição Ambiental , Peixes , Alemanha , Purificação da ÁguaRESUMO
Sulfonamide antibiotics are widely used in human and veterinary medicine. After their application, they are excreted in unchanged as well as in metabolized form. Due to incomplete elimination in wastewater treatment plants, they can be emitted into surface water. The environmental fate of both parent compounds and metabolites is currently unknown. The aim of this study was to determine the biodegradation potential of river sediment for the sulfonamide sulfamethoxazole (SMX) and its two major human metabolites N4-acetyl-SMX and SMX-N1-glucuronide using a water sediment test system. Each compound was tested in a separate series together with sterile and "water only" controls. All three compounds were efficiently removed from the test system by biodegradation in the sediment. Only for SMX-N1-glucuronide, a substantial removal in the absence of sediment was determined. Dissipation times from the aqueous phase (DT50) between 8.5 and 17.2 days were measured. Sorption to sediment was of minor importance due to the slightly basic pH of the test system. By the application of a mathematical model, biodegradation half-lives in sediment between 3.3 and 25.6 h were calculated for SMX and its metabolites. The results of this study highlight the capability of native river sediment for degrading sulfonamide antibiotics, but also the potential of human metabolites to retransform into parent SMX under environmental conditions. Based on this study, it is unlikely that SMX or its metabolites will persist or accumulate in river sediments under pH conditions where sorption is of minor importance.