Detalhe da pesquisa
1.
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.
J Transl Med
; 12: 340, 2014 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25491597
2.
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
Bioorg Med Chem Lett
; 20(15): 4324-7, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615692
3.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS Med Chem Lett
; 11(2): 188-194, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071687
4.
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
J Med Chem
; 58(23): 9382-94, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26540564