Detalhe da pesquisa
1.
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity.
J Biol Chem
; 296: 100349, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524394
2.
Practical Applications of Deep Learning To Impute Heterogeneous Drug Discovery Data.
J Chem Inf Model
; 60(6): 2848-2857, 2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32478517
3.
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers.
Cancer Res
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38833522
4.
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
J Biol Chem
; 287(50): 42180-94, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23038259
5.
Structure-based library design and the discovery of a potent and selective mast cell ß-tryptase inhibitor as an oral therapeutic agent.
Bioorg Med Chem Lett
; 22(2): 1049-54, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22192588
6.
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap.
Proteins
; 78(12): 2571-86, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20589640
7.
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.
ACS Med Chem Lett
; 11(6): 1324-1329, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551019
8.
Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
ChemMedChem
; 15(11): 955-960, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32181984
9.
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time.
ACS Med Chem Lett
; 11(6): 1205-1212, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551002
10.
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.
ACS Med Chem Lett
; 11(6): 1213-1220, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551003
11.
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors.
ACS Med Chem Lett
; 9(7): 746-751, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034612
12.
Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure
; 25(3): 506-513, 2017 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132785
13.
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
J Med Chem
; 60(16): 7099-7107, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28771350
14.
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
ACS Med Chem Lett
; 8(2): 151-156, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197303
15.
Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.
ACS Med Chem Lett
; 8(10): 1116-1121, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057061
16.
Benzotriazole-Mediated Conversions of para-H-Substituted Pyrylium, Benzo[b]pyrylium, and Xanthylium Salts into para-Position Functionalized Derivatives (An Indirect Electrophilic Substitution of Electron-Deficient Heteroaromatics).
J Org Chem
; 62(23): 8198-8200, 1997 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11671932
17.
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
Bioorg Med Chem Lett
; 15(11): 2734-7, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911249
18.
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Bioorg Med Chem
; 13(8): 2859-72, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15781396
19.
Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase.
Bioorg Med Chem Lett
; 14(24): 6053-6, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546728