Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
1.
Emerg Radiol ; 21(1): 11-5, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24048809

RESUMO

Radiation exposure during trauma care has increased in recent years. Radiation risk to providers during the care of injured patients is not well defined. We aimed to gather environmental exposure data from dosimeters placed at fixed points in the trauma bay to act as surrogates for personnel radiation exposure during trauma team activations. Forty-four (44) radiation dosimeters were placed throughout a single trauma bay in a university level 1 trauma center. We analyzed shallow (SDE) and deep dose equivalents (DDE) over 6 months. We measured distance from the radiation source for each dosimeter. Four controls were included. We recorded patient injury and X-ray data for each patient. During the study period, 417 patients were evaluated in the trauma bay under study. Mean ISS was 14.3 (range 0-75). A total of 2,107 plain X-rays were taken, with a mean of 5.1 X-rays per patient (range 0-32). Extremity films were most often performed, followed by chest and shoulder films. No measurable dose was identified with the dosimeter controls. The majority (27, 68 %) of dosimeters registered the lowest doses (<1 mSv DDE). Five dosimeters revealed doses between 1 and 2 mSv DDE. Four dosimeters registered over 2 mSv DDE, with a mean DDE of 3 mSv. Distances of less than 5 ft from the radiation source had the highest DDE dose. Maximum annual occupational DDE dose is conventionally 50 mSv. None of the dosimeters registered DDE doses over 4.31 mSv during the study period, supporting low radiation risk to providers in the trauma bay.


Assuntos
Exposição Ocupacional/análise , Doses de Radiação , Radiologia , Centros de Traumatologia , Ferimentos e Lesões/diagnóstico por imagem , Feminino , Humanos , Masculino , Estudos Prospectivos , Radiografia , Radiometria , Medição de Risco , Fatores de Risco , Raios X
2.
Bioorg Med Chem Lett ; 22(24): 7653-8, 2012 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-23127890

RESUMO

We report the discovery of a series of 4-aryl-2-aminoalkylpyrimidine derivatives as potent and selective JAK2 inhibitors. High throughput screening of our in-house compound library led to the identification of hit 1, from which optimization resulted in the discovery of highly potent and selective JAK2 inhibitors. Advanced lead 10d demonstrated a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. Based upon the desirable profile of 10d (XL019) it was advanced into clinical trials.


Assuntos
Antineoplásicos/farmacologia , Janus Quinase 2/antagonistas & inibidores , Neoplasias Experimentais/tratamento farmacológico , Prolina/análogos & derivados , Inibidores de Proteínas Quinases/farmacologia , Pirimidinas/farmacologia , Animais , Antineoplásicos/administração & dosagem , Antineoplásicos/química , Apoptose/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Cristalografia por Raios X , Cães , Relação Dose-Resposta a Droga , Haplorrinos , Ensaios de Triagem em Larga Escala , Janus Quinase 2/metabolismo , Camundongos , Camundongos Nus , Modelos Moleculares , Estrutura Molecular , Neoplasias Experimentais/patologia , Prolina/administração & dosagem , Prolina/química , Prolina/farmacologia , Inibidores de Proteínas Quinases/administração & dosagem , Inibidores de Proteínas Quinases/química , Pirimidinas/administração & dosagem , Pirimidinas/química , Ratos , Relação Estrutura-Atividade , Ensaios Antitumorais Modelo de Xenoenxerto
3.
J Med Chem ; 55(3): 1368-81, 2012 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-22214363

RESUMO

A series of subtype selective sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists are disclosed. Our high-throughput screening campaign revealed hit 1 for which an increase in potency and mouse oral exposure was achieved with minor modifications to the chemical scaffold. In vivo efficacy revealed that at high doses compounds 12 and 15 inhibited tumor growth. Further optimization of our lead series led to the discovery of proline derivatives 37 (XL541) and 38 which had similar efficacy as our first generation analogues at significantly lower doses. Analogue 37 displayed excellent pharmacokinetics and oral exposure in multiple species.


Assuntos
Antineoplásicos/síntese química , Receptores de Lisoesfingolipídeo/antagonistas & inibidores , Administração Oral , Amidas/síntese química , Amidas/farmacocinética , Amidas/farmacologia , Inibidores da Angiogênese/síntese química , Inibidores da Angiogênese/farmacocinética , Inibidores da Angiogênese/farmacologia , Compostos de Anilina/síntese química , Compostos de Anilina/farmacocinética , Compostos de Anilina/farmacologia , Animais , Antineoplásicos/farmacocinética , Antineoplásicos/farmacologia , Disponibilidade Biológica , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Cães , Haplorrinos , Ensaios de Triagem em Larga Escala , Camundongos , Neovascularização Patológica , Prolina/análogos & derivados , Prolina/síntese química , Prolina/farmacocinética , Prolina/farmacologia , Ratos , Serina/análogos & derivados , Serina/síntese química , Serina/farmacocinética , Serina/farmacologia , Estereoisomerismo , Ensaios Antitumorais Modelo de Xenoenxerto
4.
J Biosoc Sci ; 35(4): 499-512, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-14621248

RESUMO

This paper presents a new approach to cost analysis of family planning programmes that focuses on behaviour change of programme clients as the final 'output' rather than units of contraceptive services delivered, as does the familiar couple-years-of-protection index. It is useful to know how much it costs to deliver a unit of contraceptive services, but it would also seem useful to know how much it costs to change a prospective client's behaviour. The proposed approach rests on the familiar 'steps to behaviour change' paradigm and: (1) develops a methodology for applying a client-behaviour-change-centred cost analysis to programme activities; (2) tests the methodology and concepts by applying them retrospectively to a case study of mass media interventions in Egypt; (3) derives cost per unit of behaviour changes for these Egyptian communications campaigns to demonstrate the workability of the approach. This framework offers a new approach to impact evaluation that would seem to be applicable to other components of family planning and reproductive health programmes.


Assuntos
Serviços de Planejamento Familiar/economia , Serviços de Planejamento Familiar/estatística & dados numéricos , Avaliação de Programas e Projetos de Saúde/métodos , Adolescente , Adulto , Anticoncepção/economia , Anticoncepção/estatística & dados numéricos , Comportamento Contraceptivo/estatística & dados numéricos , Análise Custo-Benefício/métodos , Egito , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Necessidades e Demandas de Serviços de Saúde/economia , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Educação Sexual/métodos , Educação Sexual/estatística & dados numéricos
5.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde | ID: lis-7777

RESUMO

It presents the Nigeria family planning facility census: development of the census, advance pilot study, findings: number of sites and types of family planning facilities, ownership, services available, difficulty obtaining family planning products, unused facilities, limits, implications, possible actions, recommendations.


Assuntos
Saúde da Família , Serviços de Planejamento Familiar , Instalações de Saúde/provisão & distribuição , Instalações de Saúde/22074 , Propriedade , Projetos Piloto , Acessibilidade aos Serviços de Saúde , Dispositivos Anticoncepcionais/provisão & distribuição , Colaboração Intersetorial
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA