Detalhe da pesquisa
1.
Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
Circ Res
; 134(1): 100-113, 2024 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084599
2.
Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis.
Kidney Int
; 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38821447
3.
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.
Circ Res
; 127(6): 747-760, 2020 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32539601
4.
Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors.
Mol Pharmacol
; 99(4): 294-307, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33574047
5.
Receptor-Specific Inside-Out cAMP Signaling Regulates Cardiomyocyte Fate.
Circ Res
; 133(11): 924-926, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37943945
6.
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics.
J Comput Aided Mol Des
; 34(11): 1171-1179, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32700175
7.
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Circ Res
; 120(4): 645-657, 2017 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096195
8.
Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist.
J Am Chem Soc
; 140(30): 9624-9637, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30016089
9.
Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.
Circ Res
; 118(5): 881-97, 2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26941424
10.
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
J Neurosci
; 35(32): 11315-29, 2015 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26269639
11.
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
Circulation
; 131(4): 390-400; discussion 400, 2015 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25369805
12.
Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.
FASEB J
; 28(11): 4617-28, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25103224
13.
Epac proteins: specific ligands and role in cardiac remodelling.
Biochem Soc Trans
; 42(2): 257-64, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646227
14.
EPAC1 enhances brown fat growth and beige adipogenesis.
Nat Cell Biol
; 26(1): 113-123, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38195707
15.
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy.
J Cachexia Sarcopenia Muscle
; 15(2): 536-551, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38221511
16.
Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function.
Eur J Heart Fail
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38837573
17.
Epac in cardiac calcium signaling.
J Mol Cell Cardiol
; 58: 162-71, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23220153
18.
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
J Biol Chem
; 287(53): 44192-202, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139415
19.
The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Biochem Biophys Res Commun
; 440(3): 443-8, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099776
20.
EPAC1 Pharmacological Inhibition with AM-001 Prevents SARS-CoV-2 and Influenza A Virus Replication in Cells.
Viruses
; 15(2)2023 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36851533