Detalhe da pesquisa
1.
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species.
Xenobiotica
; : 1-13, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647387
2.
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development.
Xenobiotica
; : 1-11, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38738473
3.
Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.
Br J Cancer
; 129(9): 1383-1388, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36765177
4.
Confounding factors in exposure-response analyses and mitigation strategies for monoclonal antibodies in oncology.
Br J Clin Pharmacol
; 87(6): 2493-2501, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33217012
5.
Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma.
Invest New Drugs
; 38(3): 844-854, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31385109
6.
Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-Hodgkin Lymphoma.
Pharm Res
; 37(12): 252, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33258982
7.
A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory.
Pharm Res
; 35(6): 122, 2018 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29675616
8.
Population pharmacokinetics and exposure-response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens.
Br J Clin Pharmacol
; 83(12): 2767-2777, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28733983
9.
Platform model describing pharmacokinetic properties of vc-MMAE antibody-drug conjugates.
J Pharmacokinet Pharmacodyn
; 44(6): 537-548, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28918591
10.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27773754
11.
Assessment of CYP3A-mediated drug interaction via cytokine (IL-6) elevation for mosunetuzumab using physiologically-based pharmacokinetic modeling.
CPT Pharmacometrics Syst Pharmacol
; 13(2): 234-246, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38050329
12.
Population pharmacokinetics and exposure-response analyses of polatuzumab vedotin in patients with previously untreated DLBCL from the POLARIX study.
CPT Pharmacometrics Syst Pharmacol
; 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38622879
13.
Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings.
Adv Drug Deliv Rev
; 207: 115193, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38311111
14.
Pharmacokinetics of biologics in gastric cancer.
Clin Transl Sci
; 16(4): 564-574, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36631818
15.
Early Decision Making in a Randomized Phase II Trial of Atezolizumab in Biliary Tract Cancer Using a Tumor Growth Inhibition-Survival Modeling Framework.
Clin Pharmacol Ther
; 114(3): 644-651, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37212707
16.
Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150.
Clin Cancer Res
; 29(6): 1047-1055, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36595566
17.
Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
Clin Transl Sci
; 16(5): 823-834, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36772881
18.
Ethnic sensitivity assessment: Polatuzumab vedotin pharmacokinetics in Asian and non-Asian patients with previously untreated diffuse large B-cell lymphoma in POLARIX.
Clin Transl Sci
; 16(12): 2744-2755, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37864313
19.
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors.
Bioorg Med Chem Lett
; 22(15): 5114-7, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765900
20.
Oxidative Stress Responses and Gene Transcription of Mice under Chronic-Exposure to 2,6-Dichlorobenzoquinone.
Int J Environ Res Public Health
; 19(21)2022 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36360680