Detalhe da pesquisa
1.
The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.
Bioorg Med Chem Lett
; 29(4): 638-645, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626558
2.
Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening.
Bioorg Chem
; 86: 494-500, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30780018
3.
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
Haematologica
; 103(9): 1472-1483, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29880605
4.
Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence.
Nat Chem Biol
; 12(3): 174-9, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26780405
5.
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.
Bioorg Med Chem
; 26(8): 1751-1758, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534934
6.
Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.
Org Biomol Chem
; 14(36): 8503-19, 2016 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541268
7.
NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds.
Acta Pharmacol Sin
; 37(7): 984-93, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27238211
8.
Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1).
Org Biomol Chem
; 12(47): 9665-73, 2014 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25348815
9.
Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis.
Acta Pharmacol Sin
; 35(5): 697-706, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24632844
10.
Prion protein oligomer and its neurotoxicity.
Acta Biochim Biophys Sin (Shanghai)
; 45(6): 442-51, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557632
11.
Sodium Oligomannate Electrostatically Binds to Aß and Blocks Its Aggregation.
J Phys Chem B
; 127(9): 1983-1994, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848623
12.
¹H-NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin.
Am J Physiol Renal Physiol
; 300(4): F947-56, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21228107
13.
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.
Eur J Med Chem
; 222: 113592, 2021 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34147909
14.
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci (Weinh)
; 7(14): 2000098, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32714746
15.
A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.
Cancer Res
; 80(3): 536-548, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31732653
16.
Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.
Eur J Med Chem
; 163: 597-609, 2019 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30562696
17.
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.
Eur J Med Chem
; 184: 111767, 2019 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31622854
18.
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer Cell
; 35(4): 677-691.e10, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30991027
19.
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
J Med Chem
; 60(21): 8888-8905, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29019697
20.
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.
Chem Biol Drug Des
; 90(6): 1260-1270, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636189