Detalhe da pesquisa
1.
The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
J Biol Chem
; 300(2): 105652, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224947
2.
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177471
3.
Hydroxychloroquine Mitigates Dilated Cardiomyopathy Phenotype in Transgenic D94A Mice.
Int J Mol Sci
; 23(24)2022 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555229
4.
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.
Proc Natl Acad Sci U S A
; 115(10): E2338-E2347, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463717
5.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
FASEB J
; 33(3): 3152-3166, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365366
6.
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Proc Natl Acad Sci U S A
; 112(30): E4138-46, 2015 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124132
7.
Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.
J Biol Chem
; 289(33): 23097-23111, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24973218
8.
Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
J Mol Cell Cardiol
; 74: 318-29, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24992035
9.
In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.
Arch Biochem Biophys
; 552-553: 29-39, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374283
10.
Mechanistic basis for rescuing hypertrophic cardiomyopathy with myosin regulatory light chain phosphorylation.
Cytoskeleton (Hoboken)
; 2024 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494592
11.
Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.
J Biol Chem
; 287(3): 2156-67, 2012 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22086914
12.
The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.
J Biol Chem
; 287(44): 37362-70, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22977240
13.
Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.
Am J Physiol Heart Circ Physiol
; 305(4): H575-89, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23748425
14.
Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM.
Life (Basel)
; 13(7)2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37511838
15.
Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.
J Biol Chem
; 286(2): 1005-13, 2011 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21056975
16.
Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.
J Biol Chem
; 286(39): 34404-12, 2011 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21832052
17.
Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approach.
J Biol Chem
; 286(23): 20901-12, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21502316
18.
Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice.
Front Cardiovasc Med
; 9: 988066, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36204565
19.
Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.
J Biol Chem
; 285(36): 27785-97, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566645
20.
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin.
J Gen Physiol
; 153(7)2021 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34014247