RESUMO
MicroRNA30a (miR30a) was previously reported to serve as a tumor suppressor able to inhibit the development and progression of certain types of cancer. A number of previous studies demonstrated that zinc finger Ebox binding homeobox 2 (ZEB2) may be regulated by miR30a in clear cell renal cell carcinoma and breast cancer. However, the function of miR30a in human nasopharyngeal carcinoma (NPC) remains unclear. The present study aimed to investigate the association between miR30a and ZEB2 in NPC. Therefore, the expression levels of miR30a and ZEB2 were measured in human NPC cells and tissues from patients with NPC, and the present results suggested that the expression level of miR30a was significantly decreased in NPC tissues compared with paracancerous tissues. The direct interaction between miR30a and the untranslated region of ZEB2 was examined using the dualluciferase reporter assay, and ZEB2 was identified as a direct target of miR30a. Additionally, the effects of miR30a and ZEB2 overexpression on cell proliferation, migration, invasion and apoptosis were additionally investigated. Functional experiments identified that overexpression of miR30a increased apoptosis and suppressed cell proliferation, cell migration and cell invasion by directly targeting ZEB2. Collectively, the present study suggested that miR30a may serve an important role in the progression of NPC and may represent a novel target for the treatment of patients with NPC.