Within-Canopy Distribution of Stenoma catenifer (Lepidoptera: Elachistidae) Infestation in Avocado Orchards.

Native to the neotropics, the avocado seed moth Stenoma catenifer Walsingham (Lepidoptera: Elachistidae) is a specialist pest of the family Lauraceae and considered one of the most important pests of avocados worldwide. However, little is known regarding its spatial distribution within a single tree. Therefore, we designed a study to evaluate the effects of canopy height and aspect (i.e., side of the tree) on fruit infestation by S. catenifer larvae in avocados. The study was conducted in three commercial organic avocado orchards located in São Paulo, Brazil. At each orchard, 40 fruit from 30 random trees were sampled weekly from October 2017 through February 2018, evaluating the number of fruits infested by S. catenifer larvae at three tree heights (bottom, middle, and top). In addition, fruits on the ground were also sampled. We also evaluated the effect of the side of the tree where the fruits were collected, i.e., whether they were on the side facing the east (sunrise) or the west (sunset). Within the avocado canopy, the level of fruit infestation by S. catenifer larvae was significantly higher at the top of the trees than in the middle and bottom. Fruit on the ground had lower levels of infestation than those on the tree canopy. The level of fruit infestation was also higher on the side of avocado trees facing the east (sunrise). Understanding the within-tree distribution of S. catenifer will help to better target monitoring and control activities against this pest in avocados.

Hypofractionated radiotherapy in breast cancer: a 10-year single institution experience.

BACKGROUND: Moderately post-operative hypofractionated radiotherapy (HYPO-RT) for breast cancer is a safe and effective strategy as seen in large prospective trials. This study aimed to assess overall and disease-free survivals, local control, and acute and late toxicities in patients treated with HYPO-RT. MATERIALS AND METHODS: Data from patients submitted to post-operative HYPO-RT, with or without boost, were evaluated retrospectively. Demographic, disease, and treatment characteristics were collected. RESULTS: From March 2009 to December 2016, 393 patients were treated. Breast-conserving surgery was performed in 94.7%, immediate reconstruction after mastectomy in 6 (1.5%). Most patients (91.2%) had initial stage (0 to IIA), and chemotherapy was performed in 42.0%, HYPO-RT was mainly performed in 15 or 16 daily fractions of 267 cGy and 265 cGy, respectively. The median follow-up was 5.7 years. There were 25 deaths (6.4%) and 17 (4.3%) local recurrences. At 5 and 10 years, the overall survival, local control, and disease-free survival were, respectively, 96.0% and 79.3%, 99.2% and 94.9%, 96.6%, and 91.9%. Acute grade 3 or 4 dermatitis was observed in 0.9%. Late grade 1 or 2 occurred in less than 3% of the patients. CONCLUSION: HYPO-RT is a safe and effective radiotherapy regimen with excellent disease control and overall survival rates, with low acute and late toxicity rates.

Self-Perception of Sexual Dysfunction of Adult Brazilian Women of Reproductive Age: A Cross-Sectional Study.

Introduction: Sexual dysfunction (SD) comprises disorders in sexual desire, arousal, orgasm, and lubrication. The importance of self-perceived SD relies on its relation to personal values, sex education, and partnership. We aimed to analyze the association between self-perceived SD and the Female Sexual Function Index (FSFI) in adult women of reproductive age and the correlation between age and sexual function. Material and Methods: This analytical cross-sectional study included 285 women aged 18 to 49 years, sexually active for at least four weeks, cisgender and heterosexual, and with Internet access. Women were divided into control (CG, control group; without SD) or study group (SG, study group; with SD) and responded to a self-applicable online survey containing a sociodemographic characterization, an interview about SD knowledge, and the FSFI test. The Chi-square test of independence (χ2) analyzed the association between self-perceived SD and FSFI-assessed SD. Pearson's correlation coefficient investigated the correlation between age and FSFI. Results: Included women had a mean age of 29.57 years ± 7.11 years. Self-perceived SD showed a moderate association (Cramer's V = 0.590) with the FSFI score (χ2 [2] = 91.500; p < 0.001). A weak, negative, and significant correlation was observed between age and the FSFI desire domain (r = -0.120; p = 0.030; r2 = 1.440). Conclusion: Women with self-perceived SD were 68% more likely to present FSFI-assessed SD. Regarding the FSFI desire domain, sexual function decreased with age.

Association between menopausal status and physical function: A systematic review protocol.

INTRODUCTION: Physical function is considered an important marker of adverse health outcomes. Postmenopausal women seem to have worse physical function, but conflicting results have been reported in the literature. The aim of this systematic review is to assess the association between menopausal status and physical function in community-dwelling women. METHODS: Cross-sectional and/or longitudinal studies which objectively or subjectively assess physical function at different menopausal stages will be included. Studies conducted in institutionalized populations or with any specific medical condition that may have induced menopause (i.e. cancer or degenerative diseases) will be excluded. This systematic review protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The searches will be carried out in the Pubmed, Embase, SciELO (Scientific Electronic Library Online), LILACS (Latin American and Caribbean Literature on Health Sciences), VHL (Virtual Health Library), Scopus and Web of Science databases, using the search equation "Menopause AND (Physical Performance OR Function)". The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies will be considered to assess the methodological quality of the included studies. The selection and evaluation of the methodological quality of the studies will be carried out by independent researchers and the discrepancies will be resolved by a separate researcher. ETHICS AND DISCLOSURE: Ethical approval is not required as this is a study using secondary data. The results will be published in a scientific journal. We intend to contribute to the expansion of knowledge regarding physical function of women according to the menopause status, thus helping in the perspective of improving health and functioning. This systematic review started in January 2022 and all steps are expected to be finished by October 2022. PROSPERO REGISTRATION NUMBER: CRD42021289899.

Potentialities of iodine-enhanced micro-CT imaging in the morphological study of adult Aedes (Stegomyia) aegypti (Linnaeus, 1762) mosquitoes.

X-ray micro-computed tomography (CT) produces three-dimensional images of samples on a micrometer scale. This technique has several advantages, such as its nondestructive character and low measurement time, compared with other techniques. However, when applied to biological samples of soft tissue, the low attenuation and low effective contrast between structures pose difficulties in creating appropriate images for morphological studies. Diffusible iodine-based contrast-enhanced CT (DICE-CT), which uses iodine solutions to enhance contrast, is a viable alternative for addressing the aforementioned challenges. Given the variety of biological samples, an appropriate methodology must be adapted depending on the dimensions and morphological characteristics of the investigated object. A specimen that has not been morphologically studied by micro-CT and is of high sanitary importance is the adult Aedes aegypti mosquito. This study investigated the stage of iodine staining in the treatment of the A. aegypti mosquito to determine the most suitable staining time for the morphological study of this mosquito in adulthood. After determining the appropriate staining time, we discuss the potential of applying DICE-CT and methodology to mosquito studies. Seven A. aegypti females were treated using fixation steps with Bouin's solution, dehydration in a graded ethanol series, staining with iodine solution (1%), and washing in absolute ethanol. Only the staining step was different between samples. Each mosquito spent a varying amount of time (6-72 h) in the iodine solution (1%). For comparison, one of the mosquitoes was not stained. After treatment, the samples were scanned using the Bruker SkyScan 1172 micro-CT scanner. The reconstructed volumes and histograms were compared to determine the most suitable time. In addition, a quantitative analysis was performed based on a comparison of the attenuation profiles of the mosquito brains. Thereafter, the most suitable treatment process was selected, and two other samples were scanned after applying the selected process. Although fewer than 18 h was insufficient for an effective increase in attenuation and effective contrast, surpassing 24 h proved unnecessary and resulted in saturating the gray tones visualized through the histograms, leading to information loss. Therefore, a time of approximately 24 h was the most suitable staining time for studying adult A. aegypti. It was possible to isolate the organs of the digestive and reproductive systems of the mosquito stained for 24 h. Thus, micro-CT was confirmed to be an excellent technique in studies of individual structures of adult A. aegypti mosquitoes.

Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review.

INTRODUCTION: SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike, membrane and envelope. On physiological smell, odoriferous substances bind to proteins secreted by sustentacular cells in order to be processed by olfactory receptor neurons. Olfactory disorder is one of the main manifestations of COVID-19, however, research is still required to clarify the mechanism involved in SARS-CoV-2 induced anosmia. OBJECTIVE: This article aims to analyze current scientific evidence intended to elucidate the pathophysiological relationship between COVID-19 and the cause of olfactory disorders. METHODS: Pubmed, Embase, Scopus and ScienceDirect were used to compose this article. The research was conducted on November 24th, 2020. Original articles with experimental studies in human, animal and in vitro, short communications, viewpoint, published in the English language and between 2019 and 2020 were included, all related to the pathophysiological relationship between olfactory disorders and COVID-19 infection. RESULTS: Both human cell receptors ACE2 and TMPRSS2 are essential for the SARS-CoV-2 entrance. These receptors are mostly present in the olfactory epithelium cells, therefore, the main hypothesis is that anosmia is caused due to damage to non-neuronal cells which, thereafter, affects the normal olfactory metabolism. Furthermore, magnetic resonance imaging studies exhibit a relationship between a reduction on the neuronal epithelium and the olfactory bulb atrophy. Damage to non-neuronal cells explains the average recovery lasting a few weeks. This injury can be exacerbated by an aggressive immune response, which leads to damage to neuronal cells and stem cells inducing a persistent anosmia. Conductive anosmia is not sufficient to explain most cases of COVID-19 induced anosmia. CONCLUSION: Olfactory disorders such as anosmia and hyposmia can be caused by COVID-19, the main mechanism is associated with olfactory epithelium damage, targeting predominantly non-neuronal cells. However, neuronal cells can also be affected, worsening the condition of olfactory loss.

Influence of HRT and carbon source on the enhancement of nutrient removal in an Anaerobic-Oxic-Anoxic (AOA) system.

The eutrophication and increase in toxicity promoted by the continuous or abundant supply of nutrients in water bodies threaten the safety of drinking water and human health. In this regard, this study proposes the investigation of wastewater treatment focusing on the simultaneous removal of nitrogen and phosphorus in the anaerobic-oxic-anoxic (AOA) system. The AOA system was operated in three different stages to verify the influence of the external carbon source addition in the anoxic reactor and the reduction of hydraulic retention time (HRT) in the anaerobic and oxic reactors for nutrient removal optimization. Results showed that the best performance of the AOA system on nutrient removal was obtained in Stage 3, with the reduction of the HRT in the anaerobic and oxic reactors (HRT = 4 h) while maintaining HRT of 6.4 h in the anoxic reactor with no addition of the external carbon source. Under these conditions, the average removal efficiencies reached 98% for Chemical Oxygen Demand (COD), 88% for Total Ammonia Nitrogen (TAN), 81% for Total Kjeldahl Nitrogen (TKN), and 70% for Total Phosphorus (TP). The results also demonstrate that the highest phosphorus removal efficiency was achieved in the anoxic reactor, thus indicating the occurrence of denitrifying phosphorous removal by Denitrifying Phosphate Accumulating Organisms (DNPAOs). This configuration was efficient regarding the simultaneous removal of nitrogen and phosphorus; besides, the advantages of this system include robust configuration and excellent performance on the nutrient removal.

Intersections between adolescent fertility and obesity-pathways and research gaps focusing on Latin American populations.

Latin America has notably elevated rates of adolescent fertility and obesity in women. Although numerous studies document associations between adolescent fertility and obesity across the life course, the pathways explaining their association are insufficiently theorized, especially regarding the factors in Latin America that may underpin both. Additionally, much of the existing research is from high-income countries, where fertility and obesity are trending down. In this paper, we review the various complex pathways linking adolescent fertility and obesity, highlighting research gaps and priorities, with a particular focus on Latin American populations. We carefully consider pregnancy's distinct impact on growth trajectories during the critical period of adolescence, as well as the cumulative effect that adolescent fertility may have over the life course. We also articulate a pathway through obesity as it may contribute to early puberty and thus, to adolescent fertility. If obesity is a cause of adolescent fertility, not a result of it, or if it is a mediator of early-life exposures to adulthood obesity, these are critical distinctions for policy aiming to prevent both obesity and early fertility. Research to better understand these pathways is essential for prevention efforts against obesity and undesired adolescent fertility in Latin America.

Magnitude and temporal trend of leprosy indicators in Goiás, Brazil: an ecological study 2001-2017. / Magnitude e tendência temporal dos indicadores da hanseníase em Goiás: um estudo ecológico do período 2001-2017.

OBJECTIVE: To analyze the trend of leprosy indicators in Goiás between 2001 and 2017. METHODS: An ecological time series study was conducted. Leprosy morbidity and operational indicators were calculated using Notifiable Health Conditions Information System data. Prais-Winsten regression was used for trend analysis. RESULTS: There was a falling trend in the detection rate in the general population (Annual Percent Change [APC] = -6.8 - 95%CI -8.2;-5.4) and in children under 15 years old (APC = -7.2 - 95%CI -8.5;-5.9); a rising trend in the proportion of grade 2 disability (APC = 3.7 - 95%CI 2.0;5.3) and in the proportion of examined physical disability (APC = 0.6 - 95%CI 0.3;0.8); healing and examined contacts proportions were stable. CONCLUSION: Detection rates decreased while the proportions of grade 2 physical disability and examined physical disability increased.

Prospective Patient Reported Outcomes (PRO) Study Assessing Outcomes of Surgically Managed Ankle Fractures.

BACKGROUND: Ankle fractures are a common cause of morbidity that have increased in incidence over the past decade. The purpose of this study was to compare the outcomes and prognosis of various fracture subtypes by using 2 validated patient-reported outcome measures: the Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) and Pain Interference (PI) Computer Adaptive Tests (CATs). METHODS: Twelve-month postoperative PF and PI CATs were collected for 126 ankle fracture patients presenting between 2014 and 2017. Patients were stratified by ankle fracture subtype and refined by the presence/absence of concomitant deltoid injury or posterior malleolar fracture. Patients defined as members of vulnerable populations and patients presenting more than 2 weeks from time of injury or with prior acute ipsilateral fracture were excluded. The distribution of PF and PI T scores were assessed via a Shapiro-Wilk test and a 1-way analysis of variance. If significant differences were found between groups, pairwise comparisons were tested via Dwass, Steel, and Critchlow-Fligner multiple comparison analysis. RESULTS: Mean values for the PROMIS PF and PI for each fracture subtype were calculated and compared to reference population mean (SD) T scores of 50 (10): isolated lateral malleolar (PF: 50/PI: 51), isolated medial malleolar (PF: 52/PI: 49), bimalleolar (PF: 48/PI: 50), trimalleoar (PF: 47/PI: 51), isolated posterior malleolar (PF: 53/PI: 44), and isolated syndesmotic injury (PF: 60/PI: 46). Shapiro-Wilk test indicated a nonnormal distribution for the postoperative PROMIS PF T scores across all fracture patients (P = .0421). CONCLUSION: Operative fixation of an ankle fracture was able to return most patients to the population mean with regard to PROMIS function and pain regardless of fracture type. LEVEL OF EVIDENCE: Level II, prospective comparative study.

Construction waste as substrate in vertical subsuperficial constructed wetlands treating organic matter, ibuprofenhene, acetaminophen and ethinylestradiol from low-strength synthetic wastewater.

This study aimed to evaluate the removal of chemical oxygen demand (COD), total Kjeldahl nitrogen (TKN), total ammonia nitrogen (TAN), total phosphorus (TP), ibuprofen, acetaminophen and ethinylestradiol of synthetic effluent simulating low-strength sewage by sequencing-batch mode constructed wetlands (CWs). To verify the feasibility of using a floating macrophyte in CWs and compare different substrates, three CWs containing light expanded clay aggregates (CWL), expanded clay with porcelain tiles (CWLP) and bricks (CWB) were planted with Pistia stratiotes. The results showed that CWB achieved the highest removals of TKN (78%), TAN (70%) and TP (46%), and CWLP achieved the highest COD removal (75%). LECA favored the removal of ibuprofen (92%, p < 0.05) when compared to bricks (77%), probably by the combination of biodegradation and sorption in the systems. The highest acetaminophen removal (71% to 96%) was observed in CWL, probably via biodegradation, but no significant differences were found between the CWs (p > 0.05). Ethinylestradiol was removed 76% in CWLP and 73% in CWB, both differing statistically from CWL (p < 0.05), demonstrating that brick and the combination of clay with porcelain were better than just clay in this hormone removal. After 188 days of operation, P. stratiotes was able to uptake nitrogen and phosphorus of approximately 0.28 g and 0.25 g in CWL, 0.33 g and 0.21 g CWLP, and 0.22 g and 0.09 g in CWB of, respectively. Adsorption of nitrogen and phosphorus onto the substrates was 0.48 g and 6.84 g in CWL, 0.53 g and 5.69 g in CWLP, and 0.36 g and 10.18 g in CWB, respectively. The findings on this study suggest that adsorption was possible the main process for TP removal onto the evaluated substrates whereas microbial activity was the most probable mechanism for TN removal in the evaluated CW systems.

Prevalence of Salmonella spp. in poultry carcasses samples collected in slaughterhouses of Southern Brazil from 2006 to 2015.

INTRODUCTION: This study aimed to evaluate the prevalence of Salmonella on poultry carcasses produced in slaughterhouses of Southern Brazil participating of the Official Pathogen Reduction Program conducted by the Ministry of Agriculture, Livestock, and Supply. METHODOLOGY: From 2006 to 2015, 77,165 poultry carcasses were analyzed for presence/absence of Salmonella spp. and the results were statistically evaluated. RESULTS: Prevalence varied from 2.92% to 5.24%, with a mean percentage of 4.04%. The difference in prevalence numbers was not significant during all the period analyzed. Higher Salmonella prevalence has been reported worldwide, indicating the efficacy of Brazilian control measures implemented in the productive chain and the low risk associated to Brazilian poultry meat consumption. However, additional information about the acceptable and safe prevalence of Salmonella on poultry should be defined by risk analysis studies, considering the reality of Brazilian companies and scientific data. CONCLUSIONS: The results of the present study can be the first step for a national Risk Assessment and may contribute to improvements in self-controlling programs and with the current Brazilian poultry regulation.

New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes.

BACKGROUND: Many pediatric patients presenting with status epilepticus have no history of seizures. METHODS: We retrospectively analyzed the clinical characteristics of patients aged one month to 21 years who presented during six consecutive years with convulsive status epilepticus and without a history of seizures. New-onset refractory status epilepticus was defined as status epilepticus refractory to two lines of treatment, without an identified cause in the first 48 hours. RESULTS: Of 460 patients with status epilepticus, 79 (17.2%) presented with new-onset status epilepticus, including four (0.9%) with new-onset refractory status epilepticus. Of those patients, 54.4% were female, and the median age was 3.5 years (IQR: 1.08 to 6.75). The median seizure duration was 20 minutes (IQR: 10 to 40 minutes). Etiology was unknown in 36.7%, symptomatic in 30.3%, provoked in 16.5%, and provoked with an existing symptomatic etiology in 16.5%. Patients were followed for a median duration of 63 months (IQR: 21 to 97). The mortality rate was 3.8%. Of 55 patients who were developmentally normal at baseline, 29.1% had a significant cognitive impairment at the last follow-up, and 20% had academic difficulties or behavioral problems. Patients with symptomatic etiology had greater odds of having cognitive and behavioral problems compared with patients with unknown etiology (odds ratio = 3.83, P = 0.012). CONCLUSIONS: Patients with new-onset status epilepticus are at risk for recurrent seizures, recurrent status epilepticus, death, and subsequent cognitive-behavioral impairment. Specific monitoring and care interventions might be required in this high-risk population.

Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review / Relação fisiopatológica entre Covid‐19 e disfunção olfativa: uma revisão sistemática

Abstract Introduction SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike, membrane and envelope. On physiological smell, odoriferous substances bind to proteins secreted by sustentacular cells in order to be processed by olfactory receptor neurons. Olfactory disorder is one of the main manifestations of COVID-19, however, research is still required to clarify the mechanism involved in SARS-CoV-2 induced anosmia. Objective This article aims to analyze current scientific evidence intended to elucidate the pathophysiological relationship between COVID-19 and the cause of olfactory disorders. Methods Pubmed, Embase, Scopus and ScienceDirect were used to compose this article. The research was conducted on November 24th, 2020. Original articles with experimental studies in human, animal and in vitro, short communications, viewpoint, published in the English language and between 2019 and 2020 were included, all related to the pathophysiological relationship between olfactory disorders and COVID-19 infection. Results Both human cell receptors ACE2 and TMPRSS2 are essential for the SARS-CoV-2 entrance. These receptors are mostly present in the olfactory epithelium cells, therefore, the main hypothesis is that anosmia is caused due to damage to non-neuronal cells which, thereafter, affects the normal olfactory metabolism. Furthermore, magnetic resonance imaging studies exhibit a relationship between a reduction on the neuronal epithelium and the olfactory bulb atrophy. Damage to non-neuronal cells explains the average recovery lasting a few weeks. This injury can be exacerbated by an aggressive immune response, which leads to damage to neuronal cells and stem cells inducing a persistent anosmia. Conductive anosmia is not sufficient to explain most cases of COVID-19 induced anosmia. Conclusion Olfactory disorders such as anosmia and hyposmia can be caused by COVID-19, the main mechanism is associated with olfactory epithelium damage, targeting predominantly non-neuronal cells. However, neuronal cells can also be affected, worsening the condition of olfactory loss.

Resumo Introdução SARS‐CoV‐2 é o patógeno da Covid‐19. O vírus é composto pela proteína spike (espigão), a membrana e o envelope. No olfato fisiológico, as substâncias odoríferas se ligam a proteínas secretadas pelas células sustentaculares para serem processadas pelos neurônios receptores olfativos. O distúrbio olfativo é uma das principais manifestações da Covid‐19; entretanto, pesquisas ainda são necessárias para esclarecer o mecanismo envolvido na anosmia induzida pela SARS‐CoV‐2. Objetivos Este artigo tem como objetivo analisar as evidências científicas atuais destinadas a elucidar a relação fisiopatológica entre a Covid‐19 e a causa dos distúrbios olfativos. Método As bases de dados Pubmed, Embase, Scopus e ScienceDirect foram usadas para compor este artigo. A pesquisa foi feita em 24 de novembro de 2020. Foram incluídos artigos originais com estudos experimentais em seres humanos, animais e estudos in vitro, comunicações breves, pontos de vista, publicados na língua inglesa e entre 2019 e 2020, todos relacionados à relação fisiopatológica entre distúrbios olfativos e infecção por Covid‐19. Resultados Ambos os receptores de células humanas ACE2 e TMPRSS2 são essenciais para a penetração do SARS‐CoV‐2. Esses receptores estão presentes principalmente nas células do epitélio olfativo; portanto, a principal hipótese é que a anosmia é causada por lesão de células não neuronais que, a partir daí, afeta o metabolismo olfativo normal. Além disso, estudos de ressonância magnética mostram uma relação entre a redução do epitélio neuronal e a atrofia do bulbo olfatório. Danos às células não neuronais explicam o tempo médio de recuperação, que demora algumas semanas. Essa lesão pode ser exacerbada por uma resposta imune agressiva, que leva a danos às células neuronais e células‐tronco, induz uma anosmia persistente. A anosmia condutiva não é suficiente para explicar a maioria dos casos de anosmia induzida por Covid‐19. Conclusão Distúrbios olfativos como anosmia e hiposmia podem ser causados pela Covid‐19 e o principal mecanismo está associado à lesão do epitélio olfativo, tem como alvo células predominantemente não neuronais. Porém, células neuronais também podem ser afetadas, o que piora o quadro de perda olfativa.

Intervenções farmacêuticas em Unidade de Pronto Atendimento: uma análise farmacoterapêutica e farmacoeconômica / Pharmaceutical interventions in Emergency Care Unit: a pharmacotherapeutic and pharmacoeconomic analysis

Objetivo: Esclarecer o impacto farmacoterapêutico e farmacoeconômico das intervenções farmacêuticas em serviços de urgência e emergência. Métodos: Estudo de intervenção conduzido em uma Unidade de Pronto Atendimento. Os pacientes admitidos na pesquisa receberam acompanhamento farmacoterapêutico por meio de avaliação e intervenção na farmacoterapia. Resultados: Participaram do estudo 197 pacientes majoritariamente feminino, comórbidos, com média de idade de 43 anos ± 13. Foram realizadas intervenções em 130 destes, com aceitação de 83% por parte da equipe de assistência. As intervenções também repercutiram na farmacoeconomia, proporcionando uma redução de custos de 35% em comparação ao semestre anterior. Conclusão: Nossos resultados expressaram que a presença do farmacêutico clínico é essencial para farmacoterapias otimizadas e redução de custos hospitalares.

Objective: To clarify pharmaceutical interventions' pharmacotherapeutic and pharmacoeconomic impact on urgent and emergency services. Methods: Intervention study conducted in an Emergency Care Unit. Patients enrolled in the research received pharmacotherapeutic follow-up through evaluation and intervention in pharmacotherapy. Results: One hundred and ninety seven patients, mostly female, with comorbid conditions, with a mean age of 43 years ± 13, participated in the study. Interventions were performed in 130 of them, with an acceptance of 83% by the care team. The interventions also impacted pharmacoeconomics, providing a cost reduction of 35% compared to the previous semester. Conclusion: Our results expressed that the presence of the clinical pharmacist is essential for optimized pharmacotherapies and hospital cost reduction.

Relationship between social network and social support with early childhood caries / Relação entre rede e apoio social e cárie da primeira infância

ABSTRACT Objective: The objective of our study was to investigate the relationship between social network and social support with early childhood caries in preschool children. Methods: A transversal study with 100 children aging at most 5 years and 11 months was performed. The children underwent a clinical dental evaluation and their parents answered a structured questionnaire. Results: Dental caries was associated with time of bottle feeding (p=0.031) (RP=5.203) and number of dental appointment (p=0,010) (RP=6,293). Moreover, dental caries was also directly associated with the number of siblings living together in the same house (p=0.002) (r=0.372), while inverse correlation was found between dental caries and social support (p=0.028) (r= - 0.219). Conclusion: Preschool children whose supervisors had a better social support presented superior oral health, suggesting that social support from caregivers is associated with improved pediatric oral health.

RESUMO Objetivo: O objetivo do estudo foi investigar a relação entre rede e apoio social e a ocorrência cárie da primeira infância em pré-escolares. Métodos: Foi realizado um estudo transversal com 100 crianças de 4 a 5 anos e 11 meses de idade. Foi realizado exame bucal nas crianças por meio do International Caries Detection and Assessment System ( ICDAS e os responsáveis foram entrevistados por meio de um roteiro estruturado de perguntas. Resultados: A análise estatística foi realizada considerando um intervalo de confiança de 95%, sendo realizado o teste qui-quadrado e a regressão logística linear e multinomial A cárie dentária foi associada com a duração do uso da mamadeira (p=0,031) (RP=5,203) e a ida ao dentista (p=0,010) (RP=6,293). Observou-se, ainda, correlação direta entre número de dentes cariados e número de irmãos morando na mesma casa (p = 0,002) (r=0,372) e correlação inversa com o apoio social (p = 0,028) (r = - 0,219). Conclusão: Os pré-escolares cujos cuidadores tinham melhor apoio social apresentaram uma melhor condição de saúde bucal, sugerindo que o apoio social dos cuidadores está associado a uma maior atenção em saúde bucal infantil.

Kinetics and thermodynamics studies of silver ions adsorption onto coconut shell activated carbon.

The presence of silver in the natural water environment has been of great concern because of its toxicity, especially when it is in the free ion form (Ag(+)). This paper aims to study the adsorption kinetics of silver ions from an aqueous solution onto coconut shell activated carbon using batch methods. Batch kinetic data were fitted to the first-order model and the pseudo-second-order model, and this last equation fits correctly the experimental data. Equilibrium experiments were carried out at 30°C, 40°C, and 50°C. The adsorption isotherms were reasonably fit using Langmuir model, and the adsorption process was slightly influenced by changes in temperature. Thermodynamic parameters (ΔH°, ΔG°, and ΔS°) were determined. The adsorption process seems to be non-favorable, exothermic, and have an increase in the orderness.

Prevalencia de sífilis gestacional y congénita en el estado del Mato Grosso do Sul - Brasil, entre los años de 2010 y 2019

RESUMEN Esta investigación tuvo como objetivo informar la prevalencia de sífilis gestacional y congénita entre los años 2010 a 2019 en el estado de Mato Grosso do Sul, según datos de SINAN. Fue hecha una investigación documental y retrospectiva, con un enfoque cuantitativo. Se reportaron 8,791 casos de sífilis en mujeres embarazadas, el grupo de edad más afectado fue entre 20 y 29 años, con un total de 4,250 casos en este también con un mayor número de casos etnia parda. El diagnóstico de sífilis congénita se realizó con mayor frecuencia en una etapa reciente. Tanto las mujeres puerperales como sus parejas presentaron un tratamiento inadecuado. Con este estudio, fue posible observar un aumento en la sífilis gestacional y congénita a lo largo de los años estudiados, seguido de una caída, que puede denotar debilidades en la atención prenatal y la mujer embarazada, señalando que las mejoras son necesarias.

ABSTRACT This research aimed to report the prevalence of gestational and congenital syphilis between the years 2010 to 2019 in the state of Mato Grosso do Sul, based on data from SINAN. It was made a documentary and retrospective investigation, with a quantitative approach. 8,791 cases of syphilis were reported in pregnant women, the most affected age group was between 20 and 29 years old, with a total of 4,250 cases in this age group as also as with a greater number of cases for brown skin. The diagnosis of congenital syphilis was most often made at a recent stage. Both puerperal women and their partners presented inadequate treatment. In this study, it was possible to observe an increase in gestational and congenital syphilis over the years studied followed by a fall, which may denote weaknesses in prenatal care and the pregnant woman, pointing out that improvements are necessary.

A Baseline Patient Model to Support Testing of Medical Cyber-Physical Systems.

Medical Cyber-Physical Systems (MCPS) are currently a trending topic of research. The main challenges are related to the integration and interoperability of connected medical devices, patient safety, physiologic closed-loop control, and the verification and validation of these systems. In this paper, we focus on patient safety and MCPS validation. We present a formal patient model to be used in health care systems validation without jeopardizing the patient's health. To determine the basic patient conditions, our model considers the four main vital signs: heart rate, respiratory rate, blood pressure and body temperature. To generate the vital signs we used regression models based on statistical analysis of a clinical database. Our solution should be used as a starting point for a behavioral patient model and adapted to specific clinical scenarios. We present the modeling process of the baseline patient model and show its evaluation. The conception process may be used to build different patient models. The results show the feasibility of the proposed model as an alternative to the immediate need for clinical trials to test these medical systems.

Magnitude e tendência temporal dos indicadores da hanseníase em Goiás: um estudo ecológico do período 2001-2017 / Magnitud y tendencia temporal de los indicadores de lepra en Goiás, Brasil: un estudio ecológico en 2001-2017 / Magnitude and temporal trend of leprosy indicators in Goiás, Brazil: an ecological study 2001-2017

Objetivo: Analisar a tendência dos indicadores da hanseníase em Goiás no período de 2001 a 2017. Métodos: Foi realizado estudo ecológico de séries temporais. Indicadores de morbidade e operacionais da hanseníase foram calculados a partir de dados do Sistema de Informação de Agravos de Notificação (Sinan). Utilizou-se regressão de Prais-Winsten para análise de tendência. Resultados: Verificou-se tendência decrescente na taxa de detecção na população geral (variação percentual anual [VPA] = -6,8 - IC95% -8,2;-5,4) e em menores de 15 anos de idade (VPA = -7,2 - IC95% -8,5;-5,9); e tendência crescente na proporção de grau 2 de incapacidade física (VPA = 3,7 - IC95% 2,0;5,3) e na proporção de incapacidade física examinada (VPA = 0,6 - IC95% 0,3;0,8); as proporções de cura e de contatos examinados mostraram-se estáveis. Conclusão: As taxas de detecção diminuíram, enquanto as proporções de grau 2 de incapacidade física e de incapacidade física examinada cresceram.

Objetivo: Analizar la tendencia de los indicadores de lepra en Goiás entre 2001 y 2017. Métodos: Se realizó un estudio ecológico de series temporales. La morbilidad y los indicadores operativos se calcularon a partir de los datos del Sistema de información de Agravamientos de Notificación (Sinan). Se utilizó la regresión de Prais-Winsten para el análisis de tendencias. Resultados: Se confirmó una tendencia de disminución de la tasa de detección en la población general (Variación Porcentual Anual [VPA] = -6,8 - IC95% -8,2;-5,4) y en niños menores de 15 años (VPA = -7,2 - IC95% -8,5;-5,9); proporción creciente de incapacidad grado 2 (VPA = 3,7 - IC95% 2,0;5,3) y proporción creciente de incapacidad física examinada (VPA = 0,6 - IC95% 0,3;0,8); las proporciones de cura y contactos examinados fueron estables. Conclusión: Las tasas de detección disminuyeron mientras que aumentaron las proporciones de incapacidad física de grado 2 e incapacidad física examinada.

Objective: To analyze the trend of leprosy indicators in Goiás between 2001 and 2017. Methods: An ecological time series study was conducted. Leprosy morbidity and operational indicators were calculated using Notifiable Health Conditions Information System data. Prais-Winsten regression was used for trend analysis. Results: There was a falling trend in the detection rate in the general population (Annual Percent Change [APC] = -6.8 - 95%CI -8.2;-5.4) and in children under 15 years old (APC = -7.2 - 95%CI -8.5;-5.9); a rising trend in the proportion of grade 2 disability (APC = 3.7 - 95%CI 2.0;5.3) and in the proportion of examined physical disability (APC = 0.6 - 95%CI 0.3;0.8); healing and examined contacts proportions were stable. Conclusion: Detection rates decreased while the proportions of grade 2 physical disability and examined physical disability increased.