Detalhe da pesquisa
1.
M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model.
Am J Obstet Gynecol
; 220(5): 498.e1-498.e9, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849355
2.
Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study.
Front Neurosci
; 18: 1302714, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362023
3.
Live birth prevalence of hemolytic disease of the fetus and newborn in the United States from 1996 to 2010.
AJOG Glob Rep
; 3(2): 100203, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37229151
4.
The small molecule TGF-ß signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.
Cancer Immunol Immunother
; 61(4): 511-21, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21971588
5.
SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
Arterioscler Thromb Vasc Biol
; 28(4): 665-71, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18202322
6.
An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.
Anticancer Res
; 29(6): 2099-109, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19528470
7.
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Clin Cancer Res
; 14(12): 3966-74, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559619
8.
A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.
Cancer Res
; 67(5): 2351-9, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332368
9.
M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study.
Clin Pharmacol Ther
; 105(4): 1031-1039, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30402880
10.
Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor.
Arthritis Res Ther
; 21(1): 216, 2019 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647025
11.
Circulating Markers of Inflammation Persist in Children and Adults With Giant Aneurysms After Kawasaki Disease.
Circ Genom Precis Med
; 12(4): e002433, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30844302
12.
Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.
Int J Radiat Oncol Biol Phys
; 71(3): 829-37, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18411002
13.
Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.
J Invest Dermatol
; 126(8): 1733-44, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16741519
14.
Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.
Circulation
; 108(4): 479-85, 2003 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12860919
15.
Soluble type II transforming growth factor-beta receptor inhibits established murine malignant mesothelioma tumor growth by augmenting host antitumor immunity.
Clin Cancer Res
; 10(17): 5907-18, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15355924
16.
A Quantitative Microtiter Assay for Sialylated Glycoform Analyses Using Lectin Complexes.
J Biomol Screen
; 20(6): 768-78, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851037
17.
STAT3 Signaling Is Required for Optimal Regression of Large Established Tumors in Mice Treated with Anti-OX40 and TGFß Receptor Blockade.
Cancer Immunol Res
; 3(5): 526-35, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25627655
18.
Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).
Curr Opin Drug Discov Devel
; 7(4): 437-45, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15338953
19.
Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology.
Curr Pharm Biotechnol
; 12(12): 2190-202, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21619541
20.
A dual role for Sonic hedgehog in regulating adhesion and differentiation of neuroepithelial cells.
Dev Biol
; 261(2): 520-36, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14499657