Detalhe da pesquisa
1.
Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
Proc Natl Acad Sci U S A
; 121(12): e2310866121, 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38483996
2.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345620
3.
The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
Gynecol Oncol
; 149(3): 575-584, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29567272
4.
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab Dispos
; 42(10): 1656-62, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25063672
5.
An engineered interleukin-11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma.
Bioeng Transl Med
; 8(6): e10573, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-38023717
6.
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Blood
; 115(15): 3109-17, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130243
7.
SMPDB: The Small Molecule Pathway Database.
Nucleic Acids Res
; 38(Database issue): D480-7, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19948758
8.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Cancer Discov
; 12(6): 1482-1499, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35254416
9.
Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection.
J Pharmacol Exp Ther
; 338(1): 228-39, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21459966
10.
Efficacy of Novel Bromodomain and Extraterminal Inhibitors in Combination with Chemotherapy for Castration-Resistant Prostate Cancer.
Eur Urol Oncol
; 4(3): 437-446, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31402217
11.
BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia.
Clin Cancer Res
; 27(2): 598-607, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33148670
12.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34269576
13.
Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents.
Mol Cancer Res
; 19(2): 249-260, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33154093
14.
The Bromodomain Inhibitor, INCB057643, Targets Both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer.
Cancers (Basel)
; 13(1)2020 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33396954
15.
INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
PLoS One
; 15(4): e0231877, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315352
16.
Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies.
Clin Cancer Res
; 26(6): 1247-1257, 2020 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527168
17.
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors.
Sci Transl Med
; 12(534)2020 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32161105
18.
Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
Am J Pathol
; 172(5): 1256-70, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18385523
19.
Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.
JCI Insight
; 4(8)2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996142
20.
Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.
J Am Geriatr Soc
; 67(8): 1617-1624, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30924932