Detalhe da pesquisa
1.
Preclinical Characterization of Vadadustat (AKB-6548), an Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, for the Potential Treatment of Renal Anemia.
J Pharmacol Exp Ther
; 383(1): 11-24, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926869
2.
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Bioorg Med Chem
; 28(12): 115548, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503688
3.
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
J Pharmacol Exp Ther
; 367(1): 147-154, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076263
4.
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Biochem Pharmacol
; 209: 115418, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36693437