Detalhe da pesquisa
1.
Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
Am J Pathol
; 187(10): 2273-2287, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28734947
2.
Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors.
Invest New Drugs
; 35(4): 442-450, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28161886
3.
Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma.
Gynecol Oncol
; 132(1): 166-75, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24183729
4.
Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor.
Cancer Res
; 67(2): 555-62, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234763
5.
Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer.
Mol Cancer Ther
; 6(7): 1932-41, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17604334
6.
Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α.
Clin Cancer Res
; 24(4): 847-857, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191969
7.
Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target.
Mol Cancer Ther
; 4(3): 369-79, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15767546
8.
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.
Dis Model Mech
; 9(5): 563-71, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056048
9.
Mapping protein-ligand interactions by hydroxyl-radical protein footprinting.
Methods Mol Biol
; 261: 199-210, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15064460
10.
A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 73(3): 595-604, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24452395
11.
A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.
Cancer Biol Ther
; 15(9): 1208-18, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24921944
12.
Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.
Mol Cancer Ther
; 11(11): 2473-82, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22933705
13.
Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha.
Cancer
; 116(4 Suppl): 1018-26, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20127943
14.
Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera.
Arthritis Rheum
; 60(4): 1145-51, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19333919
15.
Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody.
Neoplasia
; 11(6): 594-604, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19484148
16.
An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.
Biochem Biophys Res Commun
; 357(4): 1142-7, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17462601
17.
Identifying protein interactions by hydroxyl-radical protein footprinting.
Curr Protoc Protein Sci
; Chapter 19: 19.9.1-19.9.11, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18429254