[Levels of growth hormone, prolactin, cortisone, aldosterone and insulin in the blood of patients with stomach cancer, before and after gastrectomy]. / Uroven' gormona rosta, prolaktina, kortizola, al'dosterona i insulina v krovi bol'nykh rakom zheludka do i posle gastréktomii.

The basal blood levels of certain hormones were determined by radioimmunologic assay in 130 patients with stomach cancer before surgery and at different periods (10-30 days, up to 1 year, 1-5 years and over 5 years) after gastrectomy. Increased levels of growth hormone and prolactin were matched by a lowered concentration of insulin. Elevated levels of cortisol and aldosterone were observed in stage IV. Within the first 10-30 days after operation, hormonal profile (except insulin) showed a tendency to normalization. At later stages, hormone levels showed various changes.

[Correlation of insulin and C-peptide secretion in oncological patients]. / Sootnoshenie sekretsii insulina i C-peptida u onkologicheskikh bol'nykh.

Insulin and C-peptide levels were studied with a radioimmunoassay in the peripheral blood serum of 44 patients with gastric and cervical cancer and 22 healthy persons. Hyperfunction of the pancreatic insular apparatus was shown in cancer patients which was expressed in a statistically significant increase in the C-peptide level. In gastric cancer patients hyperfunction of the insular apparatus was accompanied by hypoinsulinemia, and in cervical cancer patients by hormoinsulinemia. However an analysis has shown that the ratio insulin/C-peptide in gastric and cervical cancer patients was about the same and significantly lower than the control. A conclusion has been made that in spite of difference in the initial insulin concentration, the same phenomenon--acceleration of the metabolic clearance of insulin--occurs in patients with cancer of the above sites. As a result of treatment irrespective of its modality the reverse development of changes revealed before treatment took place. The C-peptide level decreased, the ratio insulin/C-peptide increased, i.e. hyperfunction of the insular apparatus disappeared and the metabolic clearance of insulin slowed down.

[Dynamic scintigraphy of the liver using 131I-rose bengal and the bile acid content of the blood following gastrectomy for cancer]. / Dinamicheskaia stsintigrafiia pecheni s 131I-bengal'skim rozovym i soderzhanie zhelchnykh kislot v krovi posle gastréktomii po povodu raka.

Liver function was studied in 84 patients with operable stomach cancer prior to and at varying times after gastrectomy using dynamic scintigraphy with 131I-rose bengal and determination by a radioimmunoassay of bile acids in the peripheral blood. A group of patients without signs of focal lesion of the liver and a history of its diseases was examined. It was shown that disorders of hepatocytic function took place before the operation. After gastrectomy the disorders were accompanied by considerable retardation of the basal secretion of bile into the intestine. At the same time an increase in the concentration of bile acids in the peripheral blood above the discriminant level of healthy persons, i.e. over 0.5 mg/l was observed. Disorders of liver function were of long duration and persistent over 1 year after gastrectomy.

[Radionuclide study of the function of the kidneys and their hormonal regulation in cancer of the uterus]. / Radionuklidnoe issledovanie funktsii pochek i ikh gormonal'naia reguliatsiia pri rake tela matki.

Methods of radionuclide renography with 131I-hippuran and a radioimmunoassay determining plasma renin activity, the level of aldosterone and cortisol were employed to study function of the kidneys and the system of the hormonal regulation of renal functions in 40 uterine body cancer patients in the time course of surgical treatment. A group of patients without a history of renal diseases was examined prior to operation 1, 3, 5, 14 days and 6-12 mos after extirpation of the uterus with appendages. It was established that the patients had basal intrarenal urodynamic disturbances and elevated renin activity. Unfavorable effects of surgical intervention occurred more frequently on the 1st day in the postoperative period when the presence of latent renal insufficiency could be detected by radionuclide methods. The process of renal function recovery was observed however it was determined by the level of preoperative disorders and did not reach the normal. There was correlation between an increase in renin activity and disturbances in intrarenal urodynamics in surgical treatment of uterine body cancer patients.