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2.
Genet Med ; 17(1): 63-7, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24946156

RESUMO

PURPOSE: With the accelerated implementation of genomic medicine, health-care providers will depend heavily on professional guidelines and recommendations. Because genomics affects many diseases across the life span, no single professional group covers the entirety of this rapidly developing field. METHODS: To pursue a discussion of the minimal elements needed to develop evidence-based guidelines in genomics, the Centers for Disease Control and Prevention and the National Cancer Institute jointly held a workshop to engage representatives from 35 organizations with interest in genomics (13 of which make recommendations). The workshop explored methods used in evidence synthesis and guideline development and initiated a dialogue to compare these methods and to assess whether they are consistent with the Institute of Medicine report "Clinical Practice Guidelines We Can Trust." RESULTS: The participating organizations that develop guidelines or recommendations all had policies to manage guideline development and group membership, and processes to address conflicts of interests. However, there was wide variation in the reliance on external reviews, regular updating of recommendations, and use of systematic reviews to assess the strength of scientific evidence. CONCLUSION: Ongoing efforts are required to establish criteria for guideline development in genomic medicine as proposed by the Institute of Medicine.


Assuntos
Medicina Baseada em Evidências , Genômica , Guias de Prática Clínica como Assunto , Medicina Baseada em Evidências/métodos , Medicina Baseada em Evidências/tendências , Genômica/métodos , Genômica/tendências , Humanos
3.
Front Genet ; 5: 73, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24782887

RESUMO

Cancer pharmacogenomics have contributed a number of important discoveries to current cancer treatment, changing the paradigm of treatment decisions. Both somatic and germline mutations are utilized to better understand the underlying biology of cancer growth and treatment response. The level of evidence required to fully translate pharmacogenomic discoveries into the clinic has relied heavily on randomized control trials. In this review, the use of observational studies, as well as, the use of adaptive trials and next generation sequencing to develop the required level of evidence for clinical implementation are discussed.

5.
Nature ; 420(6916): 703-6, 2002 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-12478301

RESUMO

The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signalling networks. Pathways will be studied intensively in two cells--B lymphocytes (the cells of the immune system) and cardiac myocytes--to facilitate quantitative modelling. One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community.


Assuntos
Linfócitos B/fisiologia , Miócitos Cardíacos/fisiologia , Projetos de Pesquisa , Pesquisadores/organização & administração , Pesquisa/organização & administração , Transdução de Sinais , Linfócitos B/citologia , Comportamento Cooperativo , Bases de Dados Factuais , Cooperação Internacional , Internet , Ligantes , Modelos Biológicos , Miócitos Cardíacos/citologia , Estados Unidos , Recursos Humanos
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