Detalhe da pesquisa
1.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Proc Natl Acad Sci U S A
; 120(1): e2211297120, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574664
2.
WDR5 is a conserved regulator of protein synthesis gene expression.
Nucleic Acids Res
; 48(6): 2924-2941, 2020 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996893
3.
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance.
Proc Natl Acad Sci U S A
; 116(50): 25260-25268, 2019 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767764
4.
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Elife
; 122024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38682900
5.
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
bioRxiv
; 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37546802
6.
Antiretroviral therapy reduces the magnitude and T cell receptor repertoire diversity of HIV-specific T cell responses without changing T cell clonotype dominance.
J Virol
; 86(8): 4213-21, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22258246
7.
Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.
J Immunol
; 186(12): 6871-85, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21562156
8.
Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.
Blood
; 116(3): 396-405, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20424187
9.
Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells.
NAR Cancer
; 4(1): zcac007, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35252869
10.
WIN site inhibition disrupts a subset of WDR5 function.
Sci Rep
; 12(1): 1848, 2022 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115608
11.
Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.
J Virol
; 84(1): 131-40, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19828602
12.
Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler.
Oncogene
; 40(20): 3593-3609, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33931740
13.
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
Elife
; 102021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33416496
14.
Impact of WIN site inhibitor on the WDR5 interactome.
Cell Rep
; 34(3): 108636, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472061
15.
Despite biased TRBV gene usage against a dominant HLA B57-restricted epitope, TCR diversity can provide recognition of circulating epitope variants.
J Immunol
; 181(7): 5137-46, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18802118
16.
Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects.
J Virol
; 82(21): 10418-28, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18715919
17.
Inhibition of MYC by the SMARCB1 tumor suppressor.
Nat Commun
; 10(1): 2014, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043611
18.
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep
; 26(11): 2916-2928.e13, 2019 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30865883
19.
B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade.
PLoS One
; 8(12): e84185, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24358343