Detalhe da pesquisa
1.
LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study.
Lancet Oncol
; 25(4): 488-500, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38547893
2.
CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling.
J Cell Mol Med
; 28(7): e18162, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494863
3.
Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models.
J Transl Med
; 21(1): 506, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37501121
4.
Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.
Cancer Immunol Immunother
; 70(10): 2851-2865, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666760
5.
IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-ß, Collagen Type I, and PD-L1/PD-1.
J Immunol
; 202(3): 787-798, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617223
6.
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.
Invest New Drugs
; 38(5): 1448-1453, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32125598
7.
An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome.
Eur J Haematol
; 100(1): 88-97, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29064587
8.
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.
Cytotherapy
; 19(6): 689-702, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28411126
9.
Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer.
Neuroendocrinology
; 105(1): 54-66, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27442441
10.
The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Immunopharmacol Immunotoxicol
; 39(4): 199-210, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28472897
11.
Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients.
Br J Cancer
; 114(8): 872-80, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27031851
12.
Gemcitabine reduces MDSCs, tregs and TGFß-1 while restoring the teff/treg ratio in patients with pancreatic cancer.
J Transl Med
; 14(1): 282, 2016 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27687804
13.
VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation.
FASEB J
; 29(1): 227-38, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361735
14.
Intranasal delivery of central nervous system-retargeted human mesenchymal stromal cells prolongs treatment efficacy of experimental autoimmune encephalomyelitis.
Immunology
; 142(3): 431-41, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24588452
15.
Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand.
Cancer Immunol Immunother
; 63(3): 273-82, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357147
16.
αB-Crystallin regulates expansion of CD11bâºGr-1⺠immature myeloid cells during tumor progression.
FASEB J
; 27(1): 151-62, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23033322
17.
T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis.
Immunology
; 140(2): 211-9, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23721329
18.
The Janus faces of CD40 in cancer.
Semin Immunol
; 21(5): 301-7, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19647448
19.
The signaling and the metabolic differences of various CAR T cell designs.
Int Immunopharmacol
; 114: 109593, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36700773
20.
Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.
Clin Cancer Res
; 29(20): 4139-4152, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37540566